Central and Systemic Effects of a Vasopressin V1 Antagonist on MAP Recovery After Haemorrhage in Rats
Central and Systemic Effects of a Vasopressin V1 Antagonist on MAP Recovery After Haemorrhage in Rats
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加压素 V1 拮抗剂对大鼠出血后 MAP 恢复的中枢和全身影响
DOI：
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发表时间：
1988
影响因子：
3
通讯作者：
R. Hatton
中科院分区：
文献类型：
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作者：
Janel V. Johnson;G. W. Bennett;R. Hatton
本研究探讨了血管（V1）加压素（AVP）受体拮抗剂的中枢和外周管理对清醒大鼠的血压，心率和AVP水平的影响。在出血前5分钟或出血后20分钟，对快速动脉出血的大鼠给予AVP V1拮抗剂[d（CH 2）5 Tyr（Me）AVP]。监测平均动脉压（MAP）45 min后，处死动物，取脑区和血浆测定AVP。静脉注射（i. v.）与生理盐水处理的对照组相比，给予10 μg kg-1的d（CH 2）5 Tyr（Me）AVP，而不是100 ng kg-1，在出血后20 - 45分钟显著降低MAP。相比之下，脑室内给予100 ng kg−1 d（CH 2）5 Tyr（Me）AVP导致MAP恢复至出血减弱，与10 μg kg−1 i. v.拮抗剂的作用相当。出血导致循环AVP水平显著升高，在10 μg kg−1 i. v. V1拮抗剂治疗的大鼠中进一步增强，但所选脑区的AVP水平没有变化。结果表明AVP在出血后MAP恢复中的作用可能是中枢介导的。
The present study examined the effects of central and peripheral administration of a vascular (V1) vasopressin (AVP) receptor antagonist on blood pressure, heart rate, and AVP levels in conscious rats. Rats subjected to rapid arterial haemorrhage were administered the AVP V1 antagonist [d(CH2)5Tyr(Me)AVP] either 5 min pre- or 20 min posthaemorrhage. Mean arterial blood pressure (MAP) was monitored for 45 min, after which the animais were killed and selected brain regions and plasma taken for AVP measurement. Intravenous (i.v.) administration of d(CH2)5Tyr(Me)AVP at 10 μg kg−1, but not 100 ng kg−1, significantly reduced MAP between 20 and 45 min posthaemorrhage compared with salinetreated controls. In contrast, administration of d(CH2)5Tyr(Me)AVP at 100 ng kg−1 intracerebroventricu-larly caused an attenuated MAP recovery to haemorrhage comparable with the effect of the antagonist at 10 μg kg−1 i.v. Haemorrhage caused a marked increase in circulating AVP levels, which was further enhanced in rats treated with the V1 antagonist at 10 μg kg−1 i.v., but no change in AVP levels of selected brain regions. The results indicate a role for AVP in MAP recovery following haemorrhage which may be centrally mediated.