Microvascular platforms for the study of platelet-vessel wall interactions.
Microvascular platforms for the study of platelet-vessel wall interactions.
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DOI：
10.1016/j.thromres.2013.12.039
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发表时间：
2014-04
影响因子：
7.5
通讯作者：
López JA
中科院分区：
文献类型：
--
作者：
Zheng Y;Chen J;López JA
血小板与内皮相互作用以调节血管完整性和屏障功能，介导炎症和免疫反应，并预防和阻止出血。在这篇综述中，我们描述了现有的工具来研究血小板与血管壁的流动依赖性相互作用。我们还讨论了我们在构建工程化微血管方面的工作，以研究血小板对内皮屏障功能、内皮发芽和静止和刺激内皮上血栓形成的作用。特别是，我们将展示使用细胞重塑基质的血小板血管壁相互作用的研究中的优势。
Platelets interact with the endothelium to regulate vascular integrity and barrier function, mediate inflammation and immune response, and prevent and arrest hemorrhage. In this review, we describe existing tools to study the flow-dependent interactions of platelets with the vessel wall. We also discuss our work on building engineered microvessels to study the roles of platelets on endothelial barrier function, endothelial sprouting, and thrombus formation on both quiescent and stimulated endothelium. In particular, we will show the advantage of using a cell-remodelable matrix in the studies of platelet-vessel wall interactions.