Transforming growth factor-β1 in carcinogenesis, progression, and therapy in cervical cancer
Transforming growth factor-β1 in carcinogenesis, progression, and therapy in cervical cancer
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DOI：
10.1007/s13277-016-5028-8
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发表时间：
2016-03
期刊：
影响因子：
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通讯作者：
Haiyan Zhu;Hui Luo;Zhaojun Shen;Xiaoli Hu;Luzhe Sun;Xueqiong Zhu
中科院分区：
文献类型：
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作者：
Haiyan Zhu;Hui Luo;Zhaojun Shen;Xiaoli Hu;Luzhe Sun;Xueqiong Zhu
转化生长因子β1（Transforming growth factor β 1，TGF-β1）是一种多功能细胞因子，在宫颈肿瘤的形成、侵袭、进展和转移中起重要作用。TGF-β1在宫颈癌前病变和早期宫颈癌中起抑癌作用，在晚期宫颈癌中起促癌作用。这种从肿瘤抑制剂到肿瘤促进剂的转变可能是由于TGF-β信号传导途径的各种改变，例如TGF-β受体和SMAD蛋白的突变或表达丧失。此外，人乳头瘤病毒的癌蛋白已显示刺激TGF-β1表达，这反过来抑制宿主免疫监视。因此，除了驱动肿瘤细胞迁移和转移外，TGF-β1被认为通过削弱宿主免疫防御在促进人乳头瘤病毒感染中起关键作用。本文就TGF-β1在宫颈癌的表达、发生、发展及治疗中的作用进行综述。更好地了解这种细胞因子在宫颈癌的发生是至关重要的关键评价这种细胞因子作为一个潜在的预后标志物和治疗靶点。
Transforming growth factor β1 (TGF-β1) is a multifunctional cytokine that plays important roles in cervical tumor formation, invasion, progression, and metastasis. TGF-β1 functions as a tumor inhibitor in precancerous lesions and early stage cancers of cervix whereas as a tumor promoter in later stage. This switch from a tumor inhibitor to a tumor promoter might be due to various alterations in TGF-β signaling pathway, such as mutations or loss of expression of TGF-β receptors and SMAD proteins. Additionally, the oncoproteins of human papillomaviruses have been shown to stimulate TGF-β1 expression, which in turn suppresses host immune surveillance. Thus, in addition to driving tumor cell migration and metastasis, TGF-β1 is believed to play a key role in promoting human papillomavirus infection by weakening host immune defense. In this article, we will discuss the role of TGF-β1 in the expression, carcinogenesis, progression, and therapy in cervical cancers. A better understanding of this cytokine in cervical carcinogenesis is essential for critical evaluation of this cytokine as a potential prognostic marker and therapeutic target.