Use of agricultural pesticides and prostate cancer risk in the agricultural health study cohort
Use of agricultural pesticides and prostate cancer risk in the agricultural health study cohort
复制标题
DOI：
10.1093/aje/kwg040
复制
发表时间：
2003-05-01
影响因子：
5
通讯作者：
Blair, A
中科院分区：
文献类型：
--
作者：
Alavanja, MCR;Samanic, C;Blair, A
作者对来自爱荷华州和北卡罗来纳州的55,332名男性农药施用者进行了一项前瞻性队列研究，研究了45种常见农药与前列腺癌发病率之间的关系。数据收集的手段，自填式问卷完成登记（1993-1997年）。癌症发病率通过基于人群的癌症登记从登记到1999年12月31日确定。计算队列的前列腺癌标准化发病率。个别农药和农药的使用模式，通过因子分析确定的比值比进行了计算。在农业健康研究队列中观察到前列腺癌标准化发病率为1.14（95%置信区间：1.05，1.24）。50岁以上的使用者使用氯化农药和甲基溴的使用与前列腺癌风险显著相关。其他几种杀虫剂显示，有前列腺癌家族史的研究对象患前列腺癌的风险显著增加，但没有家族史的研究对象则没有。观察到重要的家族史-农药相互作用。
The authors examined the relation between 45 common agricultural pesticides and prostate cancer incidence in a prospective cohort study of 55,332 male pesticide applicators from Iowa and North Carolina with no prior history of prostate cancer. Data were collected by means of self-administered questionnaires completed at enrollment (1993-1997). Cancer incidence was determined through population-based cancer registries from enrollment through December 31, 1999. A prostate cancer standardized incidence ratio was computed for the cohort. Odds ratios were computed for individual pesticides and for pesticide use patterns identified by means of factor analysis. A prostate cancer standardized incidence ratio of 1.14 (95% confidence interval: 1.05, 1.24) was observed for the Agricultural Health Study cohort. Use of chlorinated pesticides among applicators over 50 years of age and methyl bromide use were significantly associated with prostate cancer risk. Several other pesticides showed a significantly increased risk of prostate cancer among study subjects with a family history of prostate cancer but not among those with no family history. Important family history-pesticide interactions were observed.