Differential modulation of the N2 and P3 event-related potentials by response conflict and inhibition
Differential modulation of the N2 and P3 event-related potentials by response conflict and inhibition
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DOI：
10.1016/j.bandc.2015.04.004
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发表时间：
2015-07-01
影响因子：
2.5
通讯作者：
Cragg, Lucy
中科院分区：
文献类型：
--
作者：
Groom, Madeleine J.;Cragg, Lucy
背景：开发可靠和特异的认知过程神经标记物对于提高对健康和非典型脑功能的理解至关重要。尽管进行了广泛的研究，但对于认知控制的两个电生理标记物--N2和P3，是否更好地概念化为反应抑制或反应冲突的标记物，仍然存在不确定性。本研究旨在直接比较反应抑制和反应冲突对被试的N_2和P_3事件相关电位的影响。方法：对19名18~25岁健康成人进行GO/NO-GO混合侧翼任务，同时收集脑电数据。在试验之间操纵中央目标刺激和4个侧翼刺激的反应一致性，以改变反应冲突的程度。在一定比例的试验中需要抑制反应。在两个前额电极位置测量N_2波幅，在4个中线电极位置测量P_3波幅。结果：当刺激序列一致时，不一致试验的N_2波幅大于一致试验，但反应抑制不能提高N_2波幅。在需要反应抑制的试验中，P3波幅更大；这种影响在额叶电极上更为明显。与一致试验相比，不一致试验的P3波幅也有所提高。讨论：研究结果支持将N_2波幅作为反应冲突的标志，并将P3的前移作为反应抑制的标志。这一范式可以应用于临床群体，以帮助澄清注意缺陷/多动障碍(ADHD)等障碍中行动控制受损的确切性质。(C)2015 Elsevier Inc.保留所有权利。
Background: Developing reliable and specific neural markers of cognitive processes is essential to improve understanding of healthy and atypical brain function. Despite extensive research there remains uncertainty as to whether two electrophysiological markers of cognitive control, the N2 and P3, are better conceptualised as markers of response inhibition or response conflict. The present study aimed to directly compare the effects of response inhibition and response conflict on the N2 and P3 event-related potentials, within-subjects. Method: A novel hybrid go/no-go flanker task was performed by 19 healthy adults aged 18-25 years while EEG data were collected. The response congruence of a central target stimulus and 4 flanking stimuli was manipulated between trials to vary the degree of response conflict. Response inhibition was required on a proportion of trials. N2 amplitude was measured at two frontal electrode sites; P3 amplitude was measured at 4 midline electrode sites. Results: N2 amplitude was greater on incongruent than congruent trials but was not enhanced by response inhibition when the stimulus array was congruent. P3 amplitude was greater on trials requiring response inhibition; this effect was more pronounced at frontal electrodes. P3 amplitude was also enhanced on incongruent compared with congruent trials. Discussion: The findings support a role for N2 amplitude as a marker of response conflict and for the frontal shift of the P3 as a marker of response inhibition. This paradigm could be applied to clinical groups to help clarify the precise nature of impaired action control in disorders such as attention deficit/hyperactivity disorders (ADHD). (C) 2015 Elsevier Inc. All rights reserved.