DEVELOPMENTALLY REGULATED DROSOPHILA GENE FAMILY ENCODING THE FORK HEAD DOMAIN
DEVELOPMENTALLY REGULATED DROSOPHILA GENE FAMILY ENCODING THE FORK HEAD DOMAIN
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DOI：
10.1073/pnas.89.18.8754
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发表时间：
1992-09-15
影响因子：
11.1
通讯作者：
JACKLE, H
中科院分区：
文献类型：
--
作者：
HACKER, U;GROSSNIKLAUS, U;JACKLE, H
我们已经分离出7个果蝇基因通过低严格杂交的DNA探针含有编码序列的蛋白质结构域共享的啮齿动物肝细胞富集的核转录因子HNF 3A（α）和果蝇区域特异性同源异型基因叉头（fkh）的产品。以前未报道的基因编码一个110个氨基酸的保守序列，我们称之为叉头（fkh）结构域。这些fkh结构域编码基因（“FD基因”）中的两个映射到发挥分割基因功能的松散配对基因座（slp）。其他FD基因的表达模式表明，它们的蛋白质产物可能参与肠道形成，中胚层规格，和神经发育的一些特定方面。FD基因产物可能代表了一个转录因子家族，与先前鉴定的DNA结合蛋白一样，在胚胎发生期间对细胞命运的早期发育决定做出贡献。
We have isolated seven Drosophila genes by means of low-stringency hybridization to a DNA probe containing the coding sequence for the protein domain shared by the rodent hepatocyte-enriched nuclear transcription factor HNF3A(alpha) and the product of the Drosophila region-specific homeotic gene fork head (fkh). The previously unreported genes encode a 110-amino acid conserved sequence, which we call the fork head (fkh) domain. Two of these fkh-domain-encoding genes ("FD genes") map to the sloppy paired locus (slp), which exerts segmentation gene function. The expression patterns of the other FD genes suggest that their protein products are likely to be involved in gut formation, mesoderm specification, and some specific aspects of neural development. The FD gene products presumably represent a family of transcription factors that, like the previously identified DNA-binding proteins, contribute to early developmental decisions in cell fates during embryogenesis.