TUMOR-CELL STIMULATION OF COLLAGENASE PRODUCTION BY FIBROBLASTS
TUMOR-CELL STIMULATION OF COLLAGENASE PRODUCTION BY FIBROBLASTS
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DOI：
10.1016/0006-291x(82)92042-3
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发表时间：
1982-01-01
影响因子：
3.1
通讯作者：
BISWAS, C
中科院分区：
文献类型：
--
作者：
BISWAS, C
兔成纤维细胞与上皮来源的小鼠肿瘤细胞的共培养物显示，与单个细胞的培养物相比，胶原酶的产生增加。当将B-16黑色素瘤和A-10腺癌细胞而不是成纤维细胞肿瘤细胞或正常上皮细胞加入成纤维细胞中时，观察到刺激作用。这种作用依赖于正常成纤维细胞和肿瘤细胞之间的细胞比例，并由肿瘤细胞产生的可溶性因子介导。
Cocultures of rabbit fibroblasts with mouse tumor cells of epithelial origin showed increased collagenase production when compared to cultures of the individual cells. The stimulatory effect was observed when B-16 melanoma and A-10 adenocarcinoma cells, but not fibroblastic tumor cells or normal epithelial cells, were added to the fibroblasts. The effect was dependent on the cellular ratio between the normal fibroblasts and tumor cells and was mediated by a soluble factor produced by the tumor cells.