Natural products: potential treatments for cisplatin-induced nephrotoxicity.
Natural products: potential treatments for cisplatin-induced nephrotoxicity.
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天然产物：顺铂诱导肾毒性的潜在治疗方法。
DOI：
10.1038/s41401-021-00620-9
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发表时间：
2021-12
影响因子：
8.2
通讯作者：
Weng QJ
中科院分区：
文献类型：
--
作者：
Fang CY;Lou DY;Zhou LQ;Wang JC;Yang B;He QJ;Wang JJ;Weng QJ
顺铂是一种临床先进、高效的抗癌药物，用于治疗多种恶性肿瘤，如头颈癌、肺癌、睾丸癌、卵巢癌、乳腺癌等，但由于其严重的不良反应，特别是肾毒性，在临床实践中的应用有限，20%-35%的患者在顺铂给药后发生急性肾损伤（阿基）。顺铂的肾毒性作用具有累积性和剂量依赖性，通常需要减少剂量或停药。阿基的反复发作导致肾小管功能受损和急性肾衰竭、慢性肾病、尿毒症和高血压肾病。顺铂诱导的阿基的病理生理学涉及近端肾小管损伤、细胞凋亡、氧化应激、炎症和肾脏血管损伤。目前，对于顺铂引起的肾损伤尚无有效的治疗药物和方法。近年来的体内外研究表明，许多天然产物（黄酮类、皂苷类、生物碱类、多糖类、苯丙素类等）具有特定的抗氧化、抗炎和抗凋亡特性，可调节与顺铂诱导的肾损伤相关的途径。在这篇综述中，我们描述了顺铂诱导的肾毒性的分子机制，并总结了天然产物领域的最新发现，这些天然产物破坏了这些机制，以防止顺铂诱导的肾损伤，并为阿基治疗提供了潜在的策略。
Cisplatin is a clinically advanced and highly effective anticancer drug used in the treatment of a wide variety of malignancies, such as head and neck, lung, testis, ovary, breast cancer, etc. However, it has only a limited use in clinical practice due to its severe adverse effects, particularly nephrotoxicity; 20%–35% of patients develop acute kidney injury (AKI) after cisplatin administration. The nephrotoxic effect of cisplatin is cumulative and dose dependent and often necessitates dose reduction or withdrawal. Recurrent episodes of AKI result in impaired renal tubular function and acute renal failure, chronic kidney disease, uremia, and hypertensive nephropathy. The pathophysiology of cisplatin-induced AKI involves proximal tubular injury, apoptosis, oxidative stress, inflammation, and vascular injury in the kidneys. At present, there are no effective drugs or methods for cisplatin-induced kidney injury. Recent in vitro and in vivo studies show that numerous natural products (flavonoids, saponins, alkaloids, polysaccharide, phenylpropanoids, etc.) have specific antioxidant, anti-inflammatory, and anti-apoptotic properties that regulate the pathways associated with cisplatin-induced kidney damage. In this review we describe the molecular mechanisms of cisplatin-induced nephrotoxicity and summarize recent findings in the field of natural products that undermine these mechanisms to protect against cisplatin-induced kidney damage and provide potential strategies for AKI treatment.
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影响因子：
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作者：
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