Comparison of Carcinogen Biomarkers in Smokers of Menthol and Nonmenthol Cigarettes: The 2015-2016 National Health and Nutrition Examination Survey Special Sample.
Comparison of Carcinogen Biomarkers in Smokers of Menthol and Nonmenthol Cigarettes: The 2015-2016 National Health and Nutrition Examination Survey Special Sample.
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薄荷烟和非薄荷烟吸烟者致癌物生物标志物的比较：2015-2016年全国健康与营养调查特殊样本。
DOI：
10.1158/1055-9965.epi-22-0239
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发表时间：
2022-08-02
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美国食品和药物管理局（FDA）宣布其承诺禁止薄荷醇作为烟草中的特征香料。香烟薄荷醇和暴露于主流烟草烟雾中的有毒物质之间的关系还没有得到很好的表征。2015-2016年国家健康与营养调查（NHANES）的数据用于研究烟草烟雾中26种有害和潜在有害成分（HPHC）的标记物。这些包括尿液中的多环芳烃（PAH），挥发性有机化合物（VOC），和重金属的代谢产物在纯薄荷醇（n=162）和非薄荷醇（n=189）香烟吸烟者。根据薄荷醇状态比较7种多环芳烃、15种挥发性有机物和4种重金属生物标志物的尿液代谢产物。对肌酐校正浓度进行多变量分析。可替宁水平或26例HPHC中的22例无显著差异。在多环芳烃的尿液代谢物中，吸薄荷脑的人中1-羟基菲的水平低约16%。在挥发性有机物的尿液代谢产物中，吸薄荷醇香烟者的丙烯酰胺、N，N-二甲基甲酰胺和丙烯腈浓度显著降低。薄荷烟和非薄荷烟吸烟者的重金属水平相似。孟诺啡不影响尿液中可替宁水平和尼古丁代谢物比例。薄荷和非薄荷香烟提供类似水平的大多数HPHC。薄荷醇和非薄荷醇香烟的毒性结果相似。
The United States Food and Drug Administration (FDA) announced its commitment to prohibiting menthol as a characterizing flavor in tobacco. The relationship between cigarette menthol and exposure to toxic substances in mainstream tobacco smoke is not well characterized. Data from the National Health and Nutrition Examination Survey (NHANES) 2015–2016 special sample were used to study markers of 26 Harmful and Potentially Harmful Constituents (HPHCs) in tobacco smoke. These include urine metabolites of polycyclic aromatic hydrocarbons (PAHs), volatile organic compounds (VOCs), and heavy metals in exclusive menthol (n=162) and nonmenthol (n=189) cigarette smokers. Urine metabolites of 7 PAHs, 15 VOCs and 4 heavy metal biomarkers were compared by menthol status. Multivariable analyses were conducted on creatinine-adjusted concentrations. There were no significant differences in cotinine levels or in 22 of 26 HPHCs. Among the urine metabolites of PAHs, the levels of 1-hydroxyphenanthrene were about 16% lower in menthol smokers. Among the urine metabolites of VOCs, menthol cigarette smokers presented significantly lower concentrations of acrylamide, N, N-dimethylformamide and acrylonitrile. Menthol and nonmenthol smokers presented similar levels of heavy metals. Menthol did not affect the levels of cotinine and the nicotine metabolite ratio in urine. Menthol and nonmenthol cigarettes deliver similar levels of most HPHCs. Findings on toxicity are similar for menthol and nonmenthol cigarettes.