Path analysis of psychopharmacological data: catecholamine breakdown in man.
Path analysis of psychopharmacological data: catecholamine breakdown in man.
复制标题
精神药理学数据的路径分析：人体儿茶酚胺分解。
DOI：
10.1016/0165-1781(86)90061-2
复制
发表时间：
1986
影响因子：
11.3
通讯作者：
Stokes,PE
中科院分区：
文献类型：
--
作者：
Gibbons,RD;Maas,JW;Davis,JM;Swann,AC;RedmondJr,DE;Casper,RC;Hanin,I;Bowden,CL;Kocsis,J;Stokes,PE
本文应用通径分析的问题，表征代谢变化的儿茶酚胺系统时，只有静态或单一措施的前体和产物是可用的。本文采用通径分析方法对去甲肾上腺素代谢动力学模型的模拟数据进行了分析。路径分析方法基于隔室之间的相关性，而不是实际流量，在模拟模型中正确识别了手术和非手术代谢途径。此外，对正常受试者24小时尿中去甲肾上腺素、去甲肾上腺素、香草香酸、3-甲氧基-4-羟基苯乙二醇的实际数据进行通径分析。研究发现，已知不完整的代谢途径不符合这些数据，而已知的去甲肾上腺素代谢途径是通过通径分析正确识别的。这些结果表明，通径分析可以为在只有前体和产物单一值的实验情况下识别正常和异常的儿茶酚胺代谢途径提供有用的工具。
This article applies path analysis to the problem of characterizing metabolic alterations in catecholamine systems when only static or single measures of precursor and products are available. In this article, simulated data from kinetic models of norepinephrine metabolism were examined using path analysis. The method of path analysis, which is based on correlations between compartments and not actual flow, correctly identified operative and nonoperative metabolic pathways in simulated models. In addition, actual data from normal subject as to the 24-hour urinary values for norepinephrine, normetanephrine, vanillymandelic acid, and 3-methoxy-4-hydroxyphenylglycol were analyzed using path analysis. It was found that metabolic routes that are known to be incomplete did not fit these data, whereas the known metabolic pathways for norepinephrine were correctly identified using path analysis. These results suggest that path analysis may provide a useful tool in identifying normal and abnormal catecholamine metabolic pathways in experimental situations where only single values of precursor and products are available.