Cutaneous lymphoproliferative disorders associated with Epstein-Barr virus infection: a clinical overview
Cutaneous lymphoproliferative disorders associated with Epstein-Barr virus infection: a clinical overview
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DOI：
10.1016/s0923-1811(99)00084-5
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发表时间：
2000-04-01
影响因子：
4.6
通讯作者：
Kaneko, F
中科院分区：
文献类型：
--
作者：
Iwatsuki, K;Xu, ZG;Kaneko, F
eb病毒（EBV）感染与多种肿瘤有关，包括某些类型的皮肤T或自然杀伤（NK）细胞增殖性疾病。虽然EBV感染的致病作用尚不清楚，但一些在潜伏期表达的EBV基因产物被发现具有导致细胞基因表达和永生的生物学特性。此外，EBV可以利用一系列策略逃避宿主免疫应答，并维持潜伏感染。与eb病毒相关的皮肤淋巴细胞增生性疾病在亚洲很普遍，而在青少年和年轻人中感染性单核细胞增多症常见的西方国家较少见。本文综述了eb病毒感染机制的最新进展，重点介绍了eb病毒相关皮肤淋巴细胞增生性疾病的独特临床病理表现。(C) 2000爱思唯尔科学爱尔兰有限公司版权所有。
Epstein-Barr virus (EBV) infection is implicated in various kinds of neoplasms including certain types of cutaneous T or natural killer (NK) cell proliferative disorders. Although a pathogenic role of EBV infection is not clear, some EBV gene products expressed during a latency phase were found to have biological properties leading to cellular gene expression and immortalization. Furthermore, EBV can use an array of strategies to evade host immune responses, and maintain the latent infection. EBV-associated cutaneous lymphoproliferative disorders are prevalent in Asia, and less frequent in western countries where infectious mononucleosis is Common in adolescents and young adults. This review introduces recent advances on the mechanism of EBV infection, highlighting unique clinicopathologic manifestations of EBV-associated cutaneous lymphoproliferative disorders. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.