Comparison of motivations and concerns for genetic testing in hereditary colorectal and breast cancer syndromes. Electronic letter
Comparison of motivations and concerns for genetic testing in hereditary colorectal and breast cancer syndromes. Electronic letter
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DOI：
10.1111/j.1399-0004.2007.00893.x
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发表时间：
2007-11-01
影响因子：
3.5
通讯作者：
McLaughlln, J.
中科院分区：
文献类型：
--
作者：
Esplen, M. J.;Madlensky, L.;McLaughlln, J.
遗传性非息肉病性结直肠癌（HNPCC）占所有结直肠癌（CRC）病例的约1-3%。该研究的目的是检查在CRC幸存者样本进行HNPCC基因检测的动机因素，期望和心理社会功能。通过基于人群的结肠癌家族登记处招募了314例结肠直肠癌患者进行横断面调查。遗传性癌症基因检测的动机与CRC患者临床样本的动机相似，包括了解后代风险增加以及了解是否需要额外的筛查。虽然诊断时的年龄和性别与心理功能相关，但咨询后痛苦的重要预测因素是对社会支持的满意度较低，逃避-回避应对方式以及如果存在突变则会变得抑郁的预期。大多数癌症幸存者希望向亲属和医生披露测试结果。癌症幸存者报告了HNPCC基因检测的几种动机，这些动机因性别而异。一个对社会支持满意度较低的幸存者亚组和逃避-回避型应对方式担心基因检测结果的潜在影响，并在咨询后表现出更多的痛苦。研究结果对未来的研究和遗传咨询和检测过程中的潜在支持需求具有影响。
Hereditary non-polyposis colorectal cancer (HNPCC) represents about 1-3% of all cases of colorectal cancer (CRC). The objectives of the study were to examine motivational factors, expectations and psychosocial functioning in a sample of CRC survivors undergoing genetic testing for HNPCC. A cross-sectional survey of 314 colorectal cancer patients recruited through a population-based colon cancer family registry was conducted. Motivations for genetic testing for hereditary cancer were similar to those of clinic-based samples of CRC patients and included learning of the increased risk to offspring and finding out if additional screening was needed. While age at diagnosis and sex were associated with psychological functioning, significant predictors of post-counseling distress were perceived lower satisfaction with social support, an escape-avoidant coping style and the anticipation of becoming depressed if a mutation was present. Most cancer survivors anticipated disclosing test results to relatives and physicians. Cancer survivors reported several motivations for genetic testing for HNPCC that varied by sex. A subgroup of survivors with lower satisfaction with social support and an escape-avoidant coping style were worried about the potential impact of genetic test results and demonstrated more distress following counseling. Findings have implications for future research and potential support needs during the genetic counseling and testing process.