KINETICS OF HEROIN DEACETYLATION IN AQUEOUS ALKALINE-SOLUTION AND IN HUMAN-SERUM AND WHOLE-BLOOD
KINETICS OF HEROIN DEACETYLATION IN AQUEOUS ALKALINE-SOLUTION AND IN HUMAN-SERUM AND WHOLE-BLOOD
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DOI：
10.1016/s0021-9673(00)91213-5
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发表时间：
1975-01-01
期刊：
影响因子：
--
通讯作者：
NOGUCHI, TT
中科院分区：
文献类型：
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作者：
NAKAMURA, GR;THORNTON, JI;NOGUCHI, TT
用气相色谱法研究了海洛因在碱性水溶液中的水解动力学，测定了二乙酰吗啡水解成单乙酰吗啡和单乙酰吗啡水解成吗啡的连续反应。用同样方法比较了二乙酰吗啡在人全血和血清中的体外水解速率。二乙酰吗啡在血液中的水解速度是在血清中的两倍。虽然吗啡是血液中水解的最终产物，但血清中不存在。
A kinetic study of heroin hydrolysis in alkaline aqueous solution at room temperature was conducted by a gas chromatographic method to measure the consecutive reactions of diacetylmorphine to monoacetylmorphine and of monoacetylmorphine to morphine. A first-order reaction was observed in both instances, and the rate for the deacetylation of heroin was greater than that of monoacetylmorphine.The rates ofin vitrohydrolysis of diacetylmorphine in human whole blood and in serum were compared by the same method. Diacetylmorphine was hydrolyzed twice as rapidly in blood as in serum. While morphine was an end product of hydrolysis in the blood, it was absent in the serum.