A CLINICAL STUDY OF MALNUTRITION IN JAPANESE PRISONERS OF WAR
A CLINICAL STUDY OF MALNUTRITION IN JAPANESE PRISONERS OF WAR
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DOI：
10.7326/0003-4819-35-1-69
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发表时间：
1951-01-01
影响因子：
39.2
通讯作者：
BLISS, TL
中科院分区：
文献类型：
--
作者：
SCHNITKER, MA;MATTMAN, PE;BLISS, TL
1945 年，从菲律宾群岛被俘的 8000 名日本战俘中，挑选了 24 名病情最严重的人来仔细研究湿脚气和干脚气。 12 例为水肿，12 例为非水肿。在6周的观察下，通过常规病史、体格检查和多项详细的实验室检查，对两组进行比较研究。与 24 名对照者相比，所有受试者均表现出体重减轻、贫血、低蛋白血症、肠道寄生虫、低胆固醇血症、基础代谢率低、尿肌酸增加、肝功能紊乱和沉降率增加。没有人显示出心脏病（脚气-脚气-心脏）、肾脏或其他疾病来解释临床表现。对 10 个病例进行了尸检研究，有证据表明组织明显饥饿萎缩，但湿病例和干病例之间没有其他显着差异。结论是，这些病例并不代表脚气病，而是饥饿性低蛋白血症并继发胃肠功能障碍。经过治疗，幸存者的康复速度很慢。
From 8000 captured Japanese prisoners in the Philippine Islands, 1945, 24 of the most severely ill were selected for careful study for wet and dry beri-beri. Twelve were edematous, 12 not edematous. Under 6 weeks of observation with routine history, physical and many detailed laboratory examinations, comparative studies between the two groups were made. All showed weight loss, anemia, hypoproteinemia, intestinal parasites, hypocholesterolemia, low basal metabolic rates, increased urinary creatine, disturbed liver function and increased sedimentation rates compared to 24 controls. None showed heart disease (beri-beri-heart), renal or other disease to account for the clinical picture. Autopsy studies were performed on 10 cases, with evidences of marked starvation atrophy of tissues but no other significant differences between the wet and dry cases. It is concluded that these cases did not represent beri-beri, but rather starvation hypoproteinemia with secondary gastro-intes-tinal dysfunction. With treatment recovery of those that survived was slow.