3 SERIAL NEURONS IN THE INNERVATION OF THE COLON BY THE SACRAL PARASYMPATHETIC NERVE OF THE DOG
3 SERIAL NEURONS IN THE INNERVATION OF THE COLON BY THE SACRAL PARASYMPATHETIC NERVE OF THE DOG
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DOI：
10.1113/jphysiol.1985.sp015663
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发表时间：
1985-01-01
影响因子：
5.5
通讯作者：
FUKUDA, H
中科院分区：
文献类型：
--
作者：
FUKAI, K;FUKUDA, H
用电生理学和组织学方法研究了犬的骶骨副交感神经支配结肠的性质。将辣根过氧化物酶(HRP)注入远端结肠壁后，在盆丛神经节内可见大量含辣根过氧化物酶(HRP)的细胞，但在骶髓内未见。应用二甲基苯基哌嗪刺激盆神经节使远端结肠收缩。将尼古丁应用于结肠，可以减少收缩。盆丛应用六甲溴铵(C6)后，盆神经直肠束对刺激骶前根反应的复合动作电位降低或消失。电位传导速度显示节前纤维多为B纤维，节后纤维几乎全部为C纤维。盆腔神经和腹下神经变性后，电镜下可见直肠束内有大量C纤维。刺激这样的直肠束会引起结肠收缩，在将C6应用于远端结肠后，这种收缩作用减弱。可见，支配结肠的副交感神经由3个系列神经元组成，分别位于骶髓、盆丛和肌间神经丛。
Electrophysiological and histological techniques were used to study the nature of the innervation of the colon by the sacral parasympathetic nerve of the dog. Many cells which incorporate horseradish peroxidase (HRP) were observed in ganglia of the pelvic plexus, but not in the sacral cord, after HRP was injected into the wall of the distal colon. Stimulation of the pelvic ganglia by an application of dimethylphenylpiperazinium contracted the distal colon. The contraction was reduced by nicotine applied to the colon. Compound action potentials in responses of rectal strands of the pelvic nerve to stimulation of the sacral ventral roots decreased or disappeared after hexamethonium bromide (C6) was applied to the pelvic plexus. Conduction velocities of the potentials showed that most of the preganglionic fibers were B fibers, and nearly all the post-ganglionic fibers were C fibers. Many C fibers were observed by EM in the rectal strands after degeneration of the pelvic and hypogastric nerves. Stimulation of such rectal strands caused a contraction of the colon, which diminished after C6 was applied to the distal colon. Apparently, the sacral parasympathetic nerve innervating the colon comprises 3 serial neurons located in the sacral spinal cord, the pelvic plexus and the myenteric plexus.