Susceptibility Contrast and Arterial Spin Labeled Perfusion MRI in Cerebrovascular Disease
Susceptibility Contrast and Arterial Spin Labeled Perfusion MRI in Cerebrovascular Disease
复制标题
磁敏感对比和动脉自旋标记灌注 MRI 在脑血管疾病中的应用
DOI：
10.1111/j.1552-6569.2003.tb00152.x
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发表时间：
2003
影响因子：
2.4
通讯作者：
J. Detre
中科院分区：
文献类型：
--
作者：
R. Wolf;D. Alsop;M. McGarvey;J. Maldjian;Jiongjiong Wang;J. Detre
目的。直接比较已知脑血管疾病患者的动态磁敏感造影 (DSC) 和连续动脉自旋标记 (CASL) 磁共振 (MR) 灌注技术，目的是识别解释中可能存在的陷阱，并确定在此情况下互补作用的潜力。方法。对 11 名患有急性和/或慢性脑血管疾病的患者进行了 DSC 和 CASL MR 灌注研究并进行了比较。使用自动分割技术，与半球和血管区域的 DSC 灌注图（峰值时间 [TTP]、相对脑血容量 [rCBV]、脑血流量 [rCBF] 和平均通过时间 [MTT]）相比，生成 CASL 灌注测量的皮尔逊相关系数。结果。当考虑所有研究患者时，使用 DSC 灌注 MR 获得的 TTP 图在主观和客观上与 CASL 灌注 MR 测量值相关性最佳。如果排除存在严重转运延误的患者，DSC rCBF 与 CASL CBF 测量值的相关性最佳。结论。 CASL 和 DSC 灌注 MR 方法在脑血管疾病中可能具有互补作用，特别是在明显转运延迟的情况下。
Purpose. To directly compare dynamic susceptibility contrast (DSC) and continuous arterial spin labeled (CASL) magnetic resonance (MR) perfusion techniques in patients with known cerebrovascular disease, with the goals of identifying possible pitfalls in interpretation and determining potential for a complementary role in this setting. Methods. DSC and CASL MR perfusion studies were performed and compared in 11 patients with acute and/or chronic cerebrovascular disease. Using an automated segmentation technique, Pearson correlation coefficients were generated for CASL perfusion measurements compared to DSC perfusion maps (time‐to‐peak [TTP], relative cerebral blood volume [rCBV], cerebral blood flow [rCBF], and mean transit time [MTT]) by hemisphere and vascular territory. Results. TTP maps obtained using DSC perfusion MR correlated best both subjectively and objectively with CASL perfusion MRmeasurements when all patients studied were considered. If patients with a major transit delay were excluded, DSC rCBF correlated best with CASL CBF measurements. Conclusion. There may be a complementary role for CASL and DSC perfusion MR methods in cerebrovascular disease, especially in the setting of a marked transit delay.