Modelling the mosaic organization of rod and cone photoreceptors with a minimal-spacing rule
Modelling the mosaic organization of rod and cone photoreceptors with a minimal-spacing rule
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DOI：
10.1046/j.1460-9568.1999.00555.x
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发表时间：
1999-04-01
影响因子：
3.4
通讯作者：
Reese, BE
中科院分区：
文献类型：
--
作者：
Galli-Resta, L;Novelli, E;Reese, BE
光感受器的镶嵌被认为是脊椎动物神经系统中精确控制细胞定位的一个主要例子。这项研究的想法是，了解光感受器镶嵌的内在几何特征是揭示其形成的生物学机制的必要步骤。我们表明，在地松鼠的视网膜中，杆和S锥的阵列是非随机的，但只不过是一个简单的最小间距规则约束受体定位是足够的空间组织的马赛克。这个“禁区”的大小是每种细胞类型的内在特征，并且仅仅是这个域的大小的差异，其解释了相同密度下S锥阵列的规则性和棒阵列的不规则性。因此，受体嵌合体的规律性是由两个独立的生物事件产生的，一个体现了禁区，另一个指定了给定受体类型的局部密度。
The mosaic of photoreceptors is regarded as a prime example of the precise control of cellular positioning in the vertebrate nervous system. This study was undertaken with the idea that understanding the intrinsic geometrical features of photoreceptor mosaics is a necessary step to unveil the biological mechanisms governing their formation. We show in the retina of the ground squirrel that the arrays of both the rods and S cones are non-random, but that nothing more than a simple minimal-spacing rule constraining receptor positioning is sufficient to account for the spatial organization of both mosaics. The size of this 'exclusion zone' is an intrinsic characteristic of each cell type, and it is simply the difference in the size of this domain that accounts for the regularity of the S cone array and the irregularity of the rod array at identical density. Consequently, regularity in receptor mosaics is produced by two independent biological events, one embodying the exclusion zone, and another specifying the local density of a given receptor type.