Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia
Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia
复制标题
DOI：
10.1126/science.aac8608
复制
发表时间：
2016-01-01
期刊：
影响因子：
56.9
通讯作者：
Guan, Yi
中科院分区：
文献类型：
--
作者：
Sabir, Jamal S. M.;Lam, Tommy T. -Y.;Guan, Yi
中东呼吸综合征（MERS）的爆发引发了关于MERS冠状病毒（CoV）在其动物宿主中的流行和演变的问题。我们在2014年和2015年在沙特阿拉伯的监测表明，MERS CoV物种和人类CoV 229 E相关谱系的病毒以高流行率共同传播，单峰骆驼的上呼吸道经常合并感染。包括一种β冠状病毒1，我们发现单峰骆驼与人类共有三种冠状病毒。骆驼中存在几种MERS-CoV谱系，包括自2014年12月以来占主导地位的重组谱系，随后导致2015年的人类爆发。因此，骆驼是中东呼吸综合征冠状病毒维持和多样化的重要储存库，也是人类感染该病毒的来源。
Outbreaks of Middle East respiratory syndrome (MERS) raise questions about the prevalence and evolution of the MERS coronavirus (CoV) in its animal reservoir. Our surveillance in Saudi Arabia in 2014 and 2015 showed that viruses of the MERS-CoV species and a human CoV 229E-related lineage co-circulated at high prevalence, with frequent co-infections in the upper respiratory tract of dromedary camels. Including a betacoronavirus 1 species, we found that dromedary camels share three CoV species with humans. Several MERS-CoV lineages were present in camels, including a recombinant lineage that has been dominant since December 2014 and that subsequently led to the human outbreaks in 2015. Camels therefore serve as an important reservoir for the maintenance and diversification of the MERS-CoVs and are the source of human infections with this virus.