The effect of ammonia on omeprazole-induced reduction of gastric acidity in subjects with Helicobacter pylori infection
The effect of ammonia on omeprazole-induced reduction of gastric acidity in subjects with Helicobacter pylori infection
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氨水对奥美拉唑引起的幽门螺杆菌感染受试者胃酸度降低的影响
DOI：
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复制
发表时间：
2000
影响因子：
9.8
通讯作者：
A. Blum
中科院分区：
文献类型：
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作者：
P. Bercik;E. Verdú;D. Armstrong;J. Idström;C. Cederberg;M. Markert;J. Crabtree;M. Stolte;A. Blum
目的：奥美拉唑在幽门螺杆菌（H。pylori）感染后治愈。我们检验了这种差异是由于H产生氨的假设。方法：12例受试者在幽门螺杆菌治愈前、治愈后1个月和6个月，用奥美拉唑和不用奥美拉唑过夜测量胃酸和酸排出量（AO）。幽门感染结果：奥美拉唑治疗期间，胃氨（[NH3]）、总胆汁酸（[TBA]）、蛋白质浓度及血浆奥美拉唑浓度的中位数分别为0.0mmol/h、0.86mmol/h、0.86mmol/h和0.86mmol/h 1个月时（p = 0.003 vs治愈前），0.34 mmol/h（p = 0.02）治愈后6个月;中位NH3排出量在治疗前为0.17 mmol/h，在1个月时为0.03 mmol/h（p = 0.002），在治疗后6个月时为0.02 mmol/h（p = 0.005）。治疗后1个月和6个月AO和NH3输出相似。当校正[NH3]时，AO和胃pH曲线在治愈前后相似。奥美拉唑血浆水平增加治愈后和胃[TBA]不变。在奥美拉唑给药期间，幽门螺杆菌感染在很大程度上归因于氨的产生。其他酸中和物质和酸分泌的变化也可能很重要，但不涉及胃反流和奥美拉唑的药代动力学。
OBJECTIVE:Omeprazole produces a higher intragastric pH during Helicobacter pylori (H. pylori) infection than after cure. We tested the hypothesis that this difference is due to the production of ammonia by H. pylori.METHODS:Gastric acidity and acid output (AO) were measured overnight in 12 subjects, with and without omeprazole, before and 1 and 6 months after cure of H. pylori infection. Gastric ammonia ([NH3]), total bile acid ([TBA]) and protein concentrations and plasma omeprazole levels were measured.RESULTS:During omeprazole, median AO were 0.0 mmol/h before, 0.86 mmol/h (p = 0.003 vs before cure) at 1 month, and 0.34 mmol/h (p = 0.02) at 6 months after cure; median NH3 output was 0.17 mmol/h before, 0.03 mmol/h (p = 0.002) at 1 month, and 0.02 mmol/h (p = 0.005) at 6 months after cure. AO and NH3 output were similar 1 and 6 months after cure. When corrected for [NH3], AO and gastric pH curves were similar before and after cure. Omeprazole plasma levels increased after cure and gastric [TBA] were unchanged.CONCLUSIONS:The higher pH observed before cure of H. pylori during omeprazole administration is attributable, in large part, to ammonia production. Other acid-neutralizing substances and changes in acid secretion may also be important, but duodenogastric reflux and omeprazole pharmacokinetics are not involved.
通过 13C-尿素呼气试验检测幽门螺杆菌感染的最低分析要求。
DOI：
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发表时间：
1993
期刊：
The American journal of gastroenterology
影响因子：
--
作者：
Klein,PD;Graham,DY
通讯作者：
Graham,DY
正常人和十二指肠溃疡患者的酸分泌和血清胃泌素：幽门螺杆菌的作用。
DOI：
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发表时间：
1993
期刊：
The American journal of gastroenterology
影响因子：
--
作者：
Peterson,WL;Barnett,CC;EvansJr,DJ;Feldman,M;Carmody,T;Richardson,C;Walsh,J;Graham,DY
通讯作者：
Graham,DY
13CO2 测量的临床应用。
DOI：
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发表时间：
1982
期刊：
Federation proceedings
影响因子：
--
作者：
Klein,PD
通讯作者：
Klein,PD