Transcobalamin II in human seminal plasma.
Transcobalamin II in human seminal plasma.
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人精浆中的转钴胺素 II。
DOI：
10.1172/jci111282
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Bernstein,GS
中科院分区：
文献类型：
--
作者：
Carmel,R;Bernstein,GS
对钴胺素结合蛋白的研究表明，精浆是人体内转钴胺素II浓度最高的部位，其次是血液，其浓度约为十分之一。正常精液不饱和钴胺素结合能力平均为15，030 +/-7，290 pg/ml，其中转钴胺素II为11，550 +/-6，660 pg/ml。在缺乏精囊的受试者中，转钴胺素II水平显著降低（1520-1660 pg/ml），但输精管切除术后没有。这表明精囊是精液中这种蛋白质的主要来源。输精管切除术后受试者的R结合物浓度增加（9，970 +/-4，900 pg/ml vs.正常人2，980 +/-1，370 pg/ml），其他患者的R结合物浓度不同。精液中内源性钴胺素含量仅为88-699 pg/ml，主要由R结合剂携带，而不是由转钴胺素II携带。异常大的精液转钴胺素II池在生殖中的功能是未知的，但似乎不太可能仅仅与钴胺素运输需求有关，至少在男性生殖道本身。
Study of cobalamin-binding proteins revealed seminal plasma to be the most concentrated site of transcobalamin II in man. The next richest normal fluid, blood, has approximately one-tenth its concentration. Normal seminal unsaturated cobalamin-binding capacity averaged 15,030 +/- 7,290 pg/ml, of which 11,550 +/- 6,660 pg/ml was transcobalamin II. Transcobalamin II levels were markedly diminished in subjects lacking seminal vesicles (1520-1660 pg/ml), but not after vasectomy. This suggests that seminal vesicles are the chief source of this protein in semen. R binder concentration was increased in postvasectomy subjects (9,970 +/- 4,900 pg/ml vs. 2,980 +/- 1,370 pg/ml in normals) and varied in other patients. The endogenous cobalamin content of semen was only 88-699 pg/ml, and was carried largely by R binder rather than by transcobalamin II. The function of the unusually large seminal transcobalamin II pool in reproduction is unknown, but seems unlikely to be related solely to cobalamin transport needs, at least within the male reproductive tract itself.