Gd-DTPA contrast enhancement and tissue differentiation in MR imaging of experimental breast carcinoma.
Gd-DTPA contrast enhancement and tissue differentiation in MR imaging of experimental breast carcinoma.
复制标题
实验性乳腺癌 MR 成像中的 Gd-DTPA 对比增强和组织分化。
DOI：
10.1148/radiology.158.2.2417274
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发表时间：
1986
期刊：
影响因子：
19.7
通讯作者：
Winkelhake,J
中科院分区：
文献类型：
--
作者：
Revel,D;Brasch,RC;Paajanen,H;Rosenau,W;Grodd,W;Engelstad,B;Fox,P;Winkelhake,J
测试了钆-DTPA (Gd-DTPA) 增强磁共振 (MR) 成像在评估癌症中的诊断效用。研究了注射两种不同剂量（0.2 和 0.5 mmol/kg 体重）Gd-DTPA 之前和之后植入 10 只裸鼠的人乳腺癌。注射前，所有肿瘤在自旋回波图像上显示强度均匀；注射后，可以区分强增强区域和弱增强区域。组织学相关性表明，强增强区域对应于富含血管的结缔组织和明显存活的肿瘤组织，而弱增强区域对应于非血管化的坏死组织。结果表明，静脉注射顺磁剂（例如 Gd-DTPA）可以通过更好地区分肿瘤成分来提高 MR 成像的特异性和诊断准确性。
Gadolinium-DTPA (Gd-DTPA) enhancement of magnetic resonance (MR) imaging was tested for diagnostic utility in evaluating carcinoma. Human breast carcinoma implanted in ten nude mice was studied before and after injection of Gd-DTPA at two different doses (0.2 and 0.5 mmol/kg body weight). Before injection, all tumors appeared homogeneous in intensity on spin-echo images; after injection, it was possible to distinguish areas of strong enhancement from areas of weak enhancement. Histologic correlations showed that the strongly enhanced areas corresponded to richly vascularized connective tissue and apparently viable tumoral tissues, while the weakly enhanced areas corresponded to nonvascularized necrotic tissue. The results indicate that intravenously administered paramagnetic agents such as Gd-DTPA may improve the specificity and diagnostic accuracy of MR imaging by permitting better differentiation of tumor elements.