Role of SDF1 chemokine in the development of lateral line efferent and facial motor neurons
Role of SDF1 chemokine in the development of lateral line efferent and facial motor neurons
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DOI：
10.1073/pnas.0406382102
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发表时间：
2005-02-01
影响因子：
11.1
通讯作者：
Ghysen, A
中科院分区：
文献类型：
--
作者：
Sapède, D;Rossel, M;Ghysen, A
大多数感觉系统受传出神经元和传入神经元支配。传出神经支配调节受体细胞或感觉末梢的敏感性。在斑马鱼的后侧线系统中，后脑中有两个传出核。在这里，我们检查传出神经元的发育。我们发现，它们的轴突沿着侧线神经被引导向目标器官，而它们的细胞体向后迁移穿过菱形小球，以达到其在菱形小球 6/7 中的最终位置。这种迁移取决于 SDF1 趋化因子。我们发现，面核运动神经元从菱形核 4 到 6 的迁移也受到 sdf1a morphants（注射吗啉缀合反义寡核苷酸的胚胎）的影响。我们认为 SDF1/CXCR4 介导的细胞迁移优先与沿动物前后轴的运动相关。
Most sensory systems are innervated by efferent neurons as well as by afferent neurons. The efferent innervation modulates the sensitivity of the receptor cells or of the sensory terminals. In the posterior lateral line system of the zebrafish, two efferent nuclei have been described in the hindbrain. Here we examine the development of the efferent neurons. We show that their axons are guided toward the target organ along the lateral line nerve while their cell bodies migrate posteriorward across rhombomeres to achieve their final position in rhombomeres 6/7. This migration depends on the SDF1 chemokine. We show that the migration of motor neurons of the facial nucleus from rhombomere 4 to 6 is also affected in sdf1a morphants (embryos injected with morpholine-conjugated antisense oligonucleotides). We propose that SDF1/CXCR4-mediated cell migration is preferentially associated with movement along the anteroposterior axis of the animal.