Incidence and cumulative risk of childhood cataract in a cohort of 2.6 million Danish children
Incidence and cumulative risk of childhood cataract in a cohort of 2.6 million Danish children
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DOI：
10.1167/iovs.03-0635
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发表时间：
2004-05-01
影响因子：
4.4
通讯作者：
Melbye, M
中科院分区：
文献类型：
--
作者：
Haargaard, B;Wohlfahrt, J;Melbye, M
目的.确定1980 ~ 2000年丹麦儿童白内障的发病率和累积危险度。对1962年至2000年间出生的2，616，439名丹麦儿童进行了队列研究，从1980年或出生之日起（以较晚者为准），直至他们的18岁生日、死亡、移民或白内障诊断（以较早者为准）。病例从丹麦国家患者登记处（NRP）中确定，并通过审查医疗记录进行验证。他们被分为四组：先天性/婴儿（CI）白内障、外伤性白内障、并发性白内障和“其他”类型的白内障。经过诊断验证后，1311名患有白内障的儿童（59%患有CI白内障）被纳入研究。1995年至2000年期间，儿童白内障的总体累积风险为每10万名儿童108.4人。女孩和男孩之间或随时间推移（1980年至2000年），Cl、并发症和“其他”类型白内障的发病率无显著差异。相比之下，男孩的外伤性白内障发病率明显较高。在整个研究期间，尽管男孩每5年下降23%，但它仍然增加。66%的2岁以下儿童Cl性白内障在1年内接受了手术。CI白内障和并发性白内障的发病率在20年内保持稳定，表明这些疾病的危险因素保持不变，而男孩中外伤性白内障的显著下降很可能反映了行为的改变和对预防措施的重视。
PURPOSE. To determine the incidence and cumulative risk of childhood cataract in Denmark during 1980 to 2000.METHODS. A cohort of 2,616,439 Danish children born between 1962 and 2000 was followed from 1980 or from the day of birth, whichever occurred later, until their 18(th) birthday, death, emigration, or diagnosis of cataract, whichever occurred first. Cases were ascertained from the Danish National Register of Patients (NRP) and validated by reviewing the medical records. They were divided into four groups: congenital/infantile (CI) cataract, traumatic cataract, complicated cataract, and "other" types of cataract.RESULTS. After diagnostic validation, 1311 children with cataract (59% with CI cataract) were included in the study. During 1995 to 2000 the overall cumulative risk of childhood cataract was 108.4 per 100,000 children. There was no significant difference in incidence between girls and boys or over time (1980 to 2000) for Cl, complicated, and "other" types of cataract. In contrast, the incidence of traumatic cataract was significantly higher among boys. It remained increased during the entire study period despite a 23% decrease per 5 years among boys. Sixty-six percent of the children diagnosed with Cl cataract below 2 years of age underwent surgery within 1 year.CONCLUSIONS. The stable incidence during a 20-year period of CI cataract and complicated cataract indicates that risk factors for these conditions have remained unchanged, whereas the marked drop of traumatic cataract among boys most likely reflects changed behavior and an increased focus on preventive measures.