THE EFFECT OF DESALIVATION ON CORONAL AND ROOT SURFACE CARIES IN RATS
THE EFFECT OF DESALIVATION ON CORONAL AND ROOT SURFACE CARIES IN RATS
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DOI：
10.1177/00220345880670010301
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发表时间：
1988-01-01
影响因子：
7.6
通讯作者：
YOUNG, DA
中科院分区：
文献类型：
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作者：
BOWEN, WH;PEARSON, SK;YOUNG, DA
虽然在西半球的大部分地区，冠状面龋的存在正在下降，但根面龋的患病率可能会随着牙齿保留时间的延长而增加。与此同时，越来越多的人由于服用处方药而患有口干，同时明显增加了对根面龋齿的易感性。本研究试图建立一种动物模型，这将有助于探索脱唾液的影响和根面龋的发展。使动物脱唾液，用粘性放线菌和变形链球菌（sobrinus）6715感染，并喂食致龋饮食。冠状面龋在动物中迅速发展;两周后存在足够的疾病，以允许评价潜在的治疗剂。牙槽骨丢失和牙根表面病变在3 - 4周内发生。S. mutans（sobrinus）和A.所有动物都很容易建立粘滞菌;然而，随着研究的进展，后者的数量有所下降，这可能是由于高度产酸的环境。该模型将有助于研究唾液分泌不足的影响，并有助于探索减轻唾液腺功能障碍不良反应的药物。
Although the presence of coronal caries is declining in much of the Western Hemisphere, the prevalence of root surface caries is likely to increase as teeth are retained longer than heretofore. At the same time, an increasing number of the population suffer from dry mouth as a result of taking prescription drugs, with an apparent concomitant increased susceptibility to root surface caries. Tihs study attempted to develop an animal model which would aid in the exploration of the effects of desalivation and the development of root surface caries. animals were desalivated, infected with Actinomyces viscosus and Streptococcus mutans (sobrinus) 6715, and fed a cariogenic diet. Coronal caries developed rapidly in the animals; sufficient disease was present after two weeks to permit evaluation of potential therapeutic agents. Alveolar bone loss and root surface lesions developed in three to four weeks. S. mutans (sobrinus) and A. viscosus established readily in all animals; however, as the investigation progressed, populations of the latter declined, possibly because of the highly acidogenic environment. This model will facilitate investigation of the influence of hyposalivation and help in the exploration of agents to alleviate the adverse effects of salivary gland dysfunction.