Changes in the Developmental Trajectories of Striatum in Autism
Changes in the Developmental Trajectories of Striatum in Autism
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DOI：
10.1016/j.biopsych.2009.03.017
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发表时间：
2009-08-15
影响因子：
10.6
通讯作者：
Durston, Sarah
中科院分区：
文献类型：
--
作者：
Langen, Marieke;Schnack, Hugo G.;Durston, Sarah
背景：在各种神经精神障碍中，重复和刻板印象的行为与纹状体有关。然而，纹状体受累尚未在自闭症中得到确凿的证明。问题包括抗精神病药物的使用和样本之间平均年龄的差异，其中相互矛盾的结果可能反映了样本之间发育阶段的差异。方法：对188例6岁至25岁的高功能自闭症患者(99例高功能自闭症患者和89例典型发育相匹配的对照组)的脑结构磁共振测量结果进行比较。测量包括纹状体在内的脑结构的体积，以及基于体素的灰质密度评估。结果：自闭症患者和对照组之间尾状核、壳核和伏隔核的发育轨迹不同。这一结果不能通过脑容量或抗精神病药物的整体变化来解释。自闭症患者尾状核体积随年龄增长而增大，而对照组尾状核体积随年龄增长而减小。基于体素的分析表明，纹状体的变化局限于尾状核头部。总体而言，自闭症患者的尾状核体积与重复行为有关。结论：我们报道了自闭症患者纹状体发育的变化，而尾核体积与重复行为有关。这强调了纹状体在自闭症病因学中的重要性，特别是在以自闭症为特征的重复行为的发展过程中。
Background: Repetitive and stereotyped behavior has been associated with striatum in various neuropsychiatric disorders. However, striatal involvement has not yet been shown conclusively in autism. issues include the use of neuroleptic medication and differences in mean age between samples, where conflicting results may reflect differences in developmental stage between samples. The objective was to examine brain development in a homogeneous sample of subjects with high-functioning autism.Methods: Magnetic resonance measures of brain structure of 188 individuals (99 subjects with high-functioning autism and 89 typically developing, matched control subjects) aged between 6 years and 25 years were compared. Measurements included the volume of brain structures, including striatum, as well as voxel-based assessment of gray matter density.Results: Developmental trajectories of the caudate nucleus, putamen, and nucleus accumbens differed between subjects with autism and control subjects. Results were not accounted for by overall changes in brain volume or neuroleptic medication. The development of the caudate nucleus differed from typical most, as its volume increased with age in autism, while it decreased for control subjects. Voxel-based analysis showed that changes in striatum localized to the head of the caudate nucleus. Overall, caudate nucleus volume was associated with repetitive behavior in autism.Conclusions: We report changes in striatal development in autism, while caudate volume is associated with repetitive behaviors. This emphasizes the importance of striatum in the etiology of autism, in particular in the development of repetitive behavior that characterizes the disorder.