Repeatability and reproducibility of macular thickness measurements using fourier domain optical coherence tomography.
Repeatability and reproducibility of macular thickness measurements using fourier domain optical coherence tomography.
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DOI：
10.2174/1874364100903010010
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发表时间：
2009-04-20
期刊：
影响因子：
--
通讯作者：
Barrett BT
中科院分区：
文献类型：
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作者：
Bruce A;Pacey IE;Dharni P;Scally AJ;Barrett BT
评价使用Topcon 3D OCT-1000测量视力正常眼黄斑厚度的重复性和再现性。第1阶段研究了扫描的可重复性、年龄和瞳孔扩张的影响。两组（6名年轻参与者和6名老年参与者）的一只眼睛在扩张前后由1名操作员扫描5次。第2阶段研究了操作员间、访视内和访视间重现性。10名受试者的1只未散瞳眼在2次单独访视时由2名操作员扫描3次。重复扫描之间不存在显著差异（p=0.75），扩张前和扩张后也不存在显著差异（p=0.54）。在年轻组中，变化较低（95%限值± 3.62µm），并且在所有视网膜区域都具有可比性。老年组表现出更大的变化（95%限值± 7.6µm）。对于给定的视网膜位置，操作员内、访视内再现性的95%置信限为5.16µm。同一名操作员两次访视后该值增加至5.56µm，两名操作员两次访视后该值增加至6.18µm。使用3D OCT- 1000可以实现黄斑厚度测量的高水平重复性（接近6µm）。因此，在老花眼前个体中，连续就诊之间测量的黄斑厚度差异超过6µm可能反映了实际的结构变化。OCT测量在老年人中变化更大，建议进行一系列扫描，以便更容易识别离群值。
To evaluate repeatability and reproducibility of macular thickness measurements in visually normal eyes using the Topcon 3D OCT-1000. Phase 1 investigated scan repeatability, the effect of age and pupil dilation. Two groups (6 younger and 6 older participants) had one eye scanned 5 times pre and post- dilation by 1 operator. Phase 2 investigated between-operator, within and between-visit reproducibility. 10 participants had 1 un-dilated eye scanned 3 times on 2 separate visits by 2 operators. No significant difference existed between repeat scans (p=0.75) and no significant difference was found pre- and post-dilation (p=0.54). In the younger group variation was low (95% limits ± 3.62µm) and comparable across all retinal regions. The older group demonstrated greater variation (95% limits ± 7.6µm). For a given retinal location, 95% confidence limits for within-operator, within-visit reproducibility was 5.16µm. This value increased to 5.56µm for the same operator over two visits and to 6.18µm for two operators over two visits. A high level repeatability, close to 6µm, of macular thickness measurement is possible using the 3D OCT- 1000. Measured differences in macular thickness between successive visits that exceed 6µm in pre-presbyopic individuals are therefore likely to reflect actual structural change. OCT measures are more variable in older individuals and it is advisable to take a series of scans so that outliers can be more easily identified.