Ectopically Expressed IBP Promotes Cell Proliferation in Oral Squamous Cell Carcinoma
Ectopically Expressed IBP Promotes Cell Proliferation in Oral Squamous Cell Carcinoma
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异位表达的 IBP 促进口腔鳞状细胞癌的细胞增殖
DOI：
10.3109/07357907.2012.734355
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发表时间：
2012-12-01
影响因子：
2.4
通讯作者：
Li, Shu-Hui
中科院分区：
文献类型：
--
作者：
Jian, Cong-Xiang;Yang, Ming-Zhen;Li, Shu-Hui
IFN调节因子4结合蛋白（IBP）已被证明在乳腺癌等恶性肿瘤的进展中发挥重要作用，但其在口腔鳞状细胞癌（OSCC）中的功能尚不清楚。我们发现IBP在一些OSCC标本中异位表达，而在正常口腔黏膜上皮组织中不表达。IBP表达与肿瘤大小、分化、临床分期及远处转移有显著相关性。IBP显著促进OSCC细胞增殖，缩短细胞周期G1间隔，提高cyclin D1表达。这些发现提示IBP可能是OSCC的潜在治疗靶点。
IFN regulatory factor 4 binding protein (IBP) has been shown to play an important role in the progression of malignant tumors such as breast cancer cells, but its function in oral squamous cell carcinoma (OSCC) remains unclear. We found that IBP ectopically expressed in some OSCC specimens but not in normal oral mucosa epithelium tissues. IBP expression was significantly correlated with tumor size, differentiation, clinical stage, and distant metastasis. Furthermore, IBP markedly promoted OSCC cell proliferation, shortened the G1 interval in the cell cycle, and increased cyclin D1 expression. These findings suggest that IBP may be a potential therapeutic target for OSCC.