Voltage-gated sodium channels and metastatic disease.
Voltage-gated sodium channels and metastatic disease.
复制标题
DOI：
10.4161/chan.21910
复制
发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Brackenbury WJ
中科院分区：
文献类型：
--
作者：
Brackenbury WJ
电压门控Na+通道（VGSC）是一种大分子蛋白质复合物，含有成孔α亚基和较小的非成孔β亚基。VGSC在来自许多癌症的转移性细胞中表达。在这些细胞中，由α亚基携带的Na+电流促进体内迁移、侵袭和转移。相反，β亚基介导细胞粘附和突起延伸。流行的假设是VGSC在癌症中上调，通常有利于侵袭性/转移性表型，尽管机制仍不完全清楚。Nav1.5 α亚基的表达与临床乳腺癌标本中的不良预后相关，表明VGSC可作为癌症进展的预后标志物。此外，重新利用现有的VGSC阻断治疗药物可能提供一种新的策略，以改善患有转移性疾病的患者的结局，转移性疾病是癌症相关死亡的主要原因，目前还没有治愈方法。
Voltage-gated Na+ channels (VGSCs) are macromolecular protein complexes containing a pore-forming α subunit and smaller non-pore-forming β subunits. VGSCs are expressed in metastatic cells from a number of cancers. In these cells, Na+ current carried by α subunits enhances migration, invasion and metastasis in vivo. In contrast, the β subunits mediate cellular adhesion and process extension. The prevailing hypothesis is that VGSCs are up-regulated in cancer, in general favoring an invasive/metastatic phenotype, although the mechanisms are still not fully clear. Expression of the Nav1.5 α subunit associates with poor prognosis in clinical breast cancer specimens, suggesting that VGSCs may have utility as prognostic markers for cancer progression. Furthermore, repurposing existing VGSC-blocking therapeutic drugs may provide a new strategy to improve outcomes in patients suffering from metastatic disease, which is the major cause of cancer-related deaths, and for which there is currently no cure.
登录
查看更多内容
影响因子：
4.8
作者：
Andrikopoulos, Petros;Fraser, Scott P.;Djamgoz, Mustafa B. A.
通讯作者：
Djamgoz, Mustafa B. A.
影响因子：
8
作者：
Adachi, K;Toyota, M;Tokino, T
通讯作者：
Tokino, T
影响因子：
4.5
作者：
Bennett, ES;Smith, BA;Harper, JM
通讯作者：
Harper, JM
影响因子：
4.8
作者：
Andrikopoulos, Petros;Baba, Akemichi;Eccles, Suzanne A.
通讯作者：
Eccles, Suzanne A.
DOI：
10.1111/j.1742-7843.2012.00880.x
发表时间：
2012-08-01
影响因子：
3.1
作者：
Batcioglu, Kadir;Uyumlu, A. Burcin;Djamgoz, Mustafa B. A.
通讯作者：
Djamgoz, Mustafa B. A.