Room-temperature palladium-catalyzed amination of aryl bromides and chlorides and extended scope of aromatic C-N bond formation with a commercial ligand
Room-temperature palladium-catalyzed amination of aryl bromides and chlorides and extended scope of aromatic C-N bond formation with a commercial ligand
复制标题
DOI：
10.1021/jo990408i
复制
发表时间：
1999-07-23
影响因子：
3.6
通讯作者：
Alcazar-Roman, LM
中科院分区：
文献类型：
--
作者：
Hartwig, JF;Kawatsura, M;Alcazar-Roman, LM
当以1：1的比例使用Pd（0）和P（t-Bu）（3）时，芳基溴与胺的反应在室温下发生，并且芳基氯的反应在室温或70 ° C下发生。以P（t-Bu）（3）为配体时，吲哚的芳基化反应和氨基甲酸酯的新芳基化反应也发生了。
The reactions of aryl bromides with amines occurs at room temperature when using Pd(0) and P(t-Bu)(3) in a 1:1 ratio, and the reactions of aryl chlorides occur at room temperature or 70 degrees C. The arylation of indoles and the new arylation of carbamates also occur when using P(t-Bu)(3) as ligand.