Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
复制标题
全基因组关联研究的荟萃分析确定了与东亚人血压变化相关的常见变异。
作者：
我们对来自AGEN - BP联盟的19608名东亚血统受试者的收缩压（SBP）和舒张压（DBP）进行了全基因组关联研究的荟萃分析，随后在涉及10518和20247个东亚样本的两个复制阶段进行了从头基因分型。我们确定了在四个新位点（ST7L - CAPZA1、FIGN - GRB14、ENPEP和NPR3）以及TBX3附近的一个新变异体与SBP或DBP之间新的全基因组显著（P < 5×10⁻⁸）关联。除NPR3外，所有新发现均在独立样本中对SBP或DBP有显著的重复性。在欧洲血统人群中先前报道的七个位点得到了证实。在12q24.13上，我们观察到一种种族特异性关联（暗示ALDH2位点的rs671为致病变异体），它影响SBP、DBP以及与冠状动脉疾病相关的多种性状。这些发现为血压调节和潜在干预靶点提供了新的见解。
We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of East Asian ancestry from the AGEN-BP consortium followed by de novo genotypingin 2 stages of replication involving 10,518 and 20,247 East Asian samples. We identified novel genome-wide significant (P < 5 × 10−8) associations between SBP or DBP and variants at four novel loci: ST7L-CAPZA1, FIGN-GRB14, ENPEP, and NPR3, as well as a novel variant near TBX3. Except for NPR3, all novel findings were significantly replicated for SBP or DBP in independent samples. Sevenloci previously reported in populations of European descent were confirmed. On 12q24.13, we observed an ethnic specific association(implicating rs671 at the ALDH2 locus as the causal variant) that affected SBP, DBP and multiple traits related to coronary artery disease. These findings provide novel insights into blood pressure regulation and potential targets for intervention.
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影响因子：
30.8
作者：
通讯作者：
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酒精摄入和血压：实施孟德尔随机方法的系统评价。
影响因子：
15.8
作者：
Chen L;Smith GD;Harbord RM;Lewis SJ
通讯作者：
Lewis SJ
影响因子：
30.8
作者：
Marchini, Jonathan;Howie, Bryan;Donnelly, Peter
通讯作者：
Donnelly, Peter
影响因子：
8.3
作者：
Cui, JSS;Hopper, JL;Harrap, SB
通讯作者：
Harrap, SB
影响因子：
5.8
作者：
Johnson, Andrew D.;Handsaker, Robert E.;de Bakker, Paul I. W.
通讯作者：
de Bakker, Paul I. W.