Targeted Nanomaterials for Phototherapy.
Targeted Nanomaterials for Phototherapy.
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DOI：
10.7150/ntno.17694
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Lovell JF
中科院分区：
文献类型：
--
作者：
Chitgupi U;Qin Y;Lovell JF
光疗涉及用光照射靶组织。为了进一步提高选择性和效力，已经开发了许多分子靶向光敏剂和光活性纳米颗粒。主动靶向通常涉及利用配体和细胞表面受体之间的亲和力来改善靶向组织中的积累。已经探索了用于光疗的靶向配体，包括肽、蛋白质、适体和小分子。在这篇综述中，总结了最近的例子，有针对性的纳米材料用于光疗。
Phototherapies involve the irradiation of target tissues with light. To further enhance selectivity and potency, numerous molecularly targeted photosensitizers and photoactive nanoparticles have been developed. Active targeting typically involves harnessing the affinity between a ligand and a cell surface receptor for improved accumulation in the targeted tissue. Targeting ligands including peptides, proteins, aptamers and small molecules have been explored for phototherapy. In this review, recent examples of targeted nanomaterials used in phototherapy are summarized.