Activating the medial temporal lobe during oddity judgment for faces and scenes
Activating the medial temporal lobe during oddity judgment for faces and scenes
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DOI：
10.1093/cercor/bhm104
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发表时间：
2008-03-01
期刊：
影响因子：
3.7
通讯作者：
Graham, Kim S.
中科院分区：
文献类型：
--
作者：
Lee, Andy C. H.;Scahill, Victoria L.;Graham, Kim S.
在健忘症患者中发现了长期陈述性记忆以外的视觉辨别障碍，海马损伤导致场景辨别缺陷，嗅周皮层损伤影响物体辨别。为了补充这些发现，目前的功能性磁共振成像研究发现，在健康参与者中，与面部或大小奇怪相比，对新的试验独特场景的奇怪判断与后海马和海马旁皮质活动增加有关。与此相反，在不熟悉的审判独特的脸古怪的判断，当与场景或大小古怪的任务相比，嗅周和前海马的活动。随着刺激在试验中的重复，所有这些区域的活动都会减少，反映出参与者对刺激的熟悉程度不断提高。这种变化是显着的，在所有领域，除了周围的嗅皮质，右前海马，并在较小程度上，左前海马在面对奇怪的判断。一种可能性是，这些区域的活动可能并不完全反映情景记忆编码，而是部分反映了记忆领域以外的过程。因此，嗅周皮质，可能还有前海马体，可能在物体的辨别和处理中发挥更一般的作用。
Impairments in visual discrimination beyond long-term declarative memory have been found in amnesic individuals, with hippocampal lesions resulting in deficits in scene discrimination and perirhinal cortex damage affecting object discrimination. To complement these findings, the present functional magnetic resonance imaging study found that in healthy participants oddity judgment for novel trial-unique scenes, compared with face or size oddity, was associated with increased posterior hippocampus and parahippocampal cortex activity. In contrast, perirhinal and anterior hippocampus activity was observed during unfamiliar trial-unique face oddity judgment, when contrasted with scene or size oddity tasks. Activity in all of these regions decreased as the stimuli were repeated across trials, reflecting the participants' increasing familiarity with the stimuli. This change was significant in all areas, with the exception of the perirhinal cortex, right anterior hippocampus, and to a lesser extent the left anterior hippocampus during face oddity judgment. One possibility is that the activity in these regions may not reflect entirely episodic memory encoding but, in part, processes beyond the mnemonic domain. Thus, the perirhinal cortex, and possibly anterior hippocampus, may play a more generic role in the discrimination and processing of objects.