Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice.
Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice.
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BIM的损失增加了白介素7受体缺陷小鼠的T细胞产生和功能。
DOI：
10.1084/jem.20041328
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发表时间：
2004-11-01
期刊：
影响因子：
--
通讯作者：
Strasser A
中科院分区：
文献类型：
--
作者：
Pellegrini M;Bouillet P;Robati M;Belz GT;Davey GM;Strasser A
Interleukin (IL)-7 receptor (R) signaling is essential for T and B lymphopoiesis by promoting proliferation, differentiation, and survival of cells. Mice lacking either IL-7 or the IL-7Rα chain have abnormally low numbers of immature as well as mature T and B lymphocytes. Transgenic expression of the apoptosis inhibitor Bcl-2 rescues T cell development and function in IL-7Rα–deficient mice, indicating that activation of a proapoptotic Bcl-2 family member causes death of immature and mature T cells. BH3-only proteins such as Bim, which are distant proapoptotic members of the Bcl-2 family, are essential initiators of programmed cell death and stress-induced apoptosis. We generated Bim/IL-7Rα double deficient mice and found that loss of Bim significantly increased thymocyte numbers, restored near normal numbers of mature T cells in the blood and spleen, and enhanced cytotoxic T cell responses to virus infection in IL-7Rα−/− mice. These results indicate that Bim cooperates with other proapoptotic proteins in the death of IL-7–deprived T cell progenitors in vivo, but is the major inducer of this pathway to apoptosis in mature T cells. This indicates that pharmacological inhibition of Bim function might be useful for boosting immune responses in immunodeficient patients.
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影响因子：
32.4
作者：
Khaled, AR;Li, WQ;Durum, SK
通讯作者：
Durum, SK
DOI：
10.1073/pnas.2336198100
发表时间：
2003-11-25
影响因子：
11.1
作者：
Pellegrini, M;Belz, G;Strasser, A
通讯作者：
Strasser, A
影响因子：
4.4
作者：
Maraskovsky, E;Peschon, JJ;Strasser, A
通讯作者：
Strasser, A
影响因子：
15.3
作者：
Enders, A;Bouillet, P;Puthalakath, H;Xu, YK;Tarlinton, DM;Strasser, A
通讯作者：
Strasser, A
影响因子：
64.5
作者：
Akashi, K;Kondo, M;Weissman, IL
通讯作者：
Weissman, IL