ROLE OF OPIATE RECEPTORS IN THE REGULATION OF COLONIC TRANSIT
ROLE OF OPIATE RECEPTORS IN THE REGULATION OF COLONIC TRANSIT
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DOI：
10.1016/0016-5085(88)90673-7
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发表时间：
1988-06-01
期刊：
影响因子：
29.4
通讯作者：
FISHER, RS
中科院分区：
文献类型：
--
作者：
KAUFMAN, PN;KREVSKY, B;FISHER, RS
本文观察了吗啡和阿片受体拮抗剂纳洛酮对人结肠传输的影响。在交叉、双盲的方式中，在给予试验药物或对照期间，使用结肠运输造影术对两组6名正常志愿者进行研究。测试药物为吗啡（每6小时s.c.或纳洛酮（0.8mg每6小时s.c.）;对照是盐水（每6小时皮下注射1 ml）。吗啡显著延迟了盲肠和升结肠的传输（p < 0.05），减慢了几何中心的进展（p < 0.01），并减少了每48小时的排便次数（p < 0.005）。纳洛酮可加速横结肠和直肠乙状结肠的转运（p < 0.05），加速几何中心的进展（p < 0.05），但对每48 h排便次数无影响（p > 0.05）。这些结果表明，麻醉性镇痛药可能会导致便秘，部分原因是通过减缓近端结肠的结肠运输和抑制排便。纳洛酮对结肠运输的加速作用提示内源性阿片肽可能在调节人结肠运输中起抑制作用。
The effects of morphine and the opiate antagonist naloxone on human colonic transit were investigated. In a crossover, double-blind fashion, two groups of 6 normal volunteers were studied using colonic transit scintigraphy during the administration of a test drug or control. The test drugs were morphine (0.1 mg/kg every 6 h s.c.) or naloxone (0.8 mg every 6 h s.c.); control was saline (1 ml every 6 h s.c.). Morphine significantly delayed transit in the cecum and ascending colon (p < 0.05), slowed the progression of the geometric center (p < 0.01), and decreased the number of bowel movements per 48 h (p < 0.005). Naloxone accelerated transit in the transverse colon and rectosigmoid colon (p < 0.05) and accelerated the progression of the geometric center (p < 0.05), but had no effect on the number of bowel movements per 48 h (p > 0.05). These results suggest that narcotic analgesics may cause constipation in part by slowing colonic transit in the proximal colon and by inhibiting defecation. Acceleration of transit by naloxone suggests that endogenous opiate peptides may play an inhibitory role in the regulation of human colonic transit.