LIFEBRIDGE: a portable, modular, rapidly available "plug-and-play" mechanical circulatory support system.
LIFEBRIDGE: a portable, modular, rapidly available "plug-and-play" mechanical circulatory support system.
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LIFEBRIDGE：一种便携式、模块化、快速可用的“即插即用”机械循环支持系统。
DOI：
10.1016/j.athoracsur.2005.03.040
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
H. Zerkowski
中科院分区：
文献类型：
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作者：
U. Mehlhorn;Michael Brieske;U. Fischer;M. Ferrari;P. Brass;J. Fischer;H. Zerkowski
我们描述了LIFEBRIDGE，一种便携式，模块化，快速可用的“即插即用”机械循环支持系统，并报告其实验安全性评估。产品说明：模块化结构由带心肺旁路电路的一次性患者模块、控制模块、带电源的基本模块、嵌入式PC和用户界面组成。该系统重约20 kg，具有模块化设计，并且具有允许在5分钟内动作的半自动预充和防止空气栓塞的7步空气消除程序。实验在8只猪（85 ± 10 kg）中，我们使用中心（右心房和升主动脉）插管（n = 4）或外周（髂动脉）插管（n = 4）研究了该系统。中央插管的泵流量为5.7 ± 0.2 L/min，外周插管的泵流量为4.1 ± 0.2 L/min，产生了足够的动物灌注和气体交换。使用主动脉内8 MHz多普勒设备，我们证明了高达100 mL的静脉空气团被有效地去除，从而避免了空气栓塞。改变动物和LIFEBRIDGE之间的高度并不影响其正常操作。结论初步评估表明，LIFEBRIDGE可快速使用，提供足够的灌注和气体交换，并且即使在模拟运输条件下也能安全运行。
PURPOSEWe describe the LIFEBRIDGE, a portable, modular, rapidly available “plug-and-play” mechanical circulatory support system, and report its experimental safety evaluation. DESCRIPTION: The modular construction consists of a disposable patient module with cardiopulmonary bypass circuit, control module, and base module with power supply, emdedded PC, and user interface. The system weighs about 20 kg, has a modular design, and has semi-automatic priming that allows action within 5 minutes, and a 7-step air elimination program that prevents air embolization.EVALUATIONIn eight pigs (85 ± 10 kg) we investigated this system using central (right atrium and ascending aorta) cannulation (n = 4) or peripheral (iliac) cannulation (n = 4). Pump flows were 5.7 ± 0.2 L/min with central and 4.1 ± 0.2 L/min with peripheral cannulation, yielding sufficient animal perfusion and gas exchange. Using an intraaortic 8-MHz Doppler device, we demonstrated that venous air boluses of up to 100 mL were effectively removed, thus avoiding air embolization. Changing heights between animals and LIFEBRIDGE did not affect its proper action.CONCLUSIONSThis initial evaluation demonstrates that the LIFEBRIDGE is rapidly available, provides adequate perfusion and gas exchange, and operates safely even under simulated transport conditions.