Notes from the field: how a molecular geneticist got wet.
Notes from the field: how a molecular geneticist got wet.
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现场笔记：分子遗传学家如何湿身。
DOI：
10.1002/gene.20076
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
Peichel,CatherineL
中科院分区：
文献类型：
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作者：
Peichel,CatherineL
当我在南加州长大的时候，我想做很多事情，包括医生、律师、兽医和第一位女总统。但我最爱的还是海洋，我尽可能多地在海滩度过，在海浪中游泳，寻找贝壳，探索潮汐池。所以我一直有一种潜在的愿望，想成为一名海洋生物学家，住在船上，跟着海豚到处走。但是当我上大学的时候，我决定要成为一名整形外科医生，并正式开始了我的医学预科课程，最后主修了分子和细胞生物学，重点是遗传学。但那些潜伏的成为海洋生物学家的愿望不断涌现，我在北卡罗来纳州的博福特的杜克海洋实验室度过了大三的夏天。这是我第一次真实的接触科学和科学家，我喜欢它。任何关于整形外科的想法都消失了，我想成为一名科学家。我特别喜欢住在海洋实验室，在那里我可以花一整天的时间做分子生物学，所有的空闲时间都在海洋中游泳和探索。但是，当到了申请博士课程的时候，我决定，虽然我喜欢海洋生物学，但分子生物学和遗传学是我研究生物学问题所需要的工具。我想有一天我可以用这些工具来探索海洋生物学。所以我没有向夏威夷大学提交申请，而是去了普林斯顿大学。在那里，我加入了汤姆·沃格特的实验室，接受了老鼠发育遗传学方面的优秀培训。但有时在实验室里的那些漫长的日子里，什么都不工作，格拉德院似乎永远不会结束，我会想我真的想成为一名野外生物学家，在那里我可以在外面与“真实的”生物体一起工作。然而，当我完成博士学位时，我不知何故忘记了做野外工作和海洋生物学的潜在愿望。我决定留在发育遗传学的世界里，但幸运的是，我被斯坦福大学的大卫金斯利实验室录取为博士后。
When I was growing up in Southern California, I wanted to be many things, including a doctor, a lawyer, a veterinarian, and the first woman president. But the thing I loved the most was the ocean, and I spent as much time as possible at the beach, swimming in the waves, combing for shells, and exploring the tide pools. So I have always had this lurking desire to become a marine biologist, live on a boat, and follow dolphins around. But when I went to college, I had decided that I was going to be an orthopedic surgeon and duly embarked on my pre-med courses and ended up with a major in Molecular and Cellular Biology with an emphasis on Genetics. But those lurking desires to be a marine biologist kept popping up and I spent the summer after my junior year at the Duke Marine Lab in Beaufort, North Carolina. This was my first real exposure to science and scientists and I loved it. Any ideas about orthopedic surgery were gone, and I wanted to be a scientist. I particularly loved living at the marine lab, where I got to spend all day doing molecular biology and all my free time swimming and exploring in the ocean. But when it came time to apply to PhD programs that fall, I decided that although I loved marine biology, molecular biology and genetics were the tools that I needed to study biological problems. I thought that someday I could use those tools to explore marine biology. So I never did submit my application to the University of Hawaii and instead went to Princeton University. There, I joined Tom Vogt’s lab and received excellent training in mouse developmental genetics. But sometimes during those long days in the lab when nothing was working and it seemed like grad school would never end, I would think about how I really wanted to be a field biologist, where I could be outside working with “real” organisms.However, when I finished my PhD, I somehow forgot about that lurking desire to do fieldwork and marine biology. I decided to stay within the world of developmental genetics, but fortunately was accepted as a post-doc in David Kingsley’s lab at Stanford Uni-