MYASTHENIC IMMUNOGLOBULIN ACCELERATES ACETYLCHOLINE-RECEPTOR DEGRADATION
MYASTHENIC IMMUNOGLOBULIN ACCELERATES ACETYLCHOLINE-RECEPTOR DEGRADATION
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DOI：
10.1126/science.850793
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发表时间：
1977-01-01
期刊：
影响因子：
56.9
通讯作者：
DRACHMAN, DB
中科院分区：
文献类型：
--
作者：
KAO, I;DRACHMAN, DB
培养的大鼠骨骼肌细胞对乙酰胆碱受体的降解由125 I从结合的125 I-标记的α-乙酰胆碱受体中的释放来确定。银环蛇毒素向培养基中加入重症肌无力患者的免疫球蛋白可加速降解速率，平均降解速率为8.51 ± 0.01。0.44%/h，而平均控制速率为3.97 ± 0.99%/h。0.14%/h（P. .001）。人类重症肌无力的自身免疫发病机制可能与此相似。
Degradation of acetylcholine receptors by cultured rat skeletal muscle cells was determined from the release of 125I from bound 125I-labeled .alpha.-bungarotoxin. Addition of immunoglobulin from patients with myasthenia gravis to the culture medium accelerated the degradation rate to a mean of 8.51 .+-. 0.44%/h, compared with the mean control rate of 3.97 .+-. 0.14%/h (P .mchlt. .001). A similar mechanism may possibly be involved in the autoimmune pathogenesis of myasthenia gravis in man.