Short report:: Failure of standard treatment with praziquantel in two returned travelers with Schistosoma haematobium infection
Short report:: Failure of standard treatment with praziquantel in two returned travelers with Schistosoma haematobium infection
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DOI：
10.4269/ajtmh.2006.74.342
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发表时间：
2006-02-01
影响因子：
3.3
通讯作者：
Corachan, M
中科院分区：
文献类型：
--
作者：
Alonso, D;Muñoz, J;Corachan, M
吡喹酮（PZQ）40 mg/kg单次给药仍然是治疗由S. mansoni和S.在所有临床环境中使用。耐药性的实验研究进展及近年来分离到的沙门氏菌。对高剂量PZQ具有天然耐受性的曼氏菌株引起了对这种剂量是否足够的关注。我们描述了两名西班牙旅客与泌尿生殖道血吸虫病引起的S。重复的标准治疗未能清除感染的嗜血杆菌。
A single 40 mg/kg dose of praziquantel (PZQ) continues to be the standard treatment for schistosomiasis caused by S. mansoni and S. haematobium in all clinical settings. Experimental development of drug resistance and the recent isolation of S. mansoni strains with a natural tolerance to high doses of PZQ have raised concerns over the adequacy of such a dose. We describe two Spanish travelers with genitourinary schistosomiasis caused by S. haematobium in whom repeated standard treatment failed to clear the infection.