AUTOREGULATION OF BRAIN CIRCULATION IN SEVERE ARTERIAL HYPERTENSION
AUTOREGULATION OF BRAIN CIRCULATION IN SEVERE ARTERIAL HYPERTENSION
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DOI：
10.1136/bmj.1.5852.507
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发表时间：
1973-01-01
影响因子：
105.7
通讯作者：
LASSEN, NA
中科院分区：
文献类型：
--
作者：
STRANDGAARD, S;OLESEN, J;LASSEN, NA
采用动静脉氧差法研究了重度高血压患者和正常血压对照者的脑血流量。降低血压以研究自动调节的下限（低于脑血流量降低的压力）和脑缺氧的压力极限。在高血压患者中，这两个极限都向上移动，可能是由于小动脉壁肥大。这些发现对抗高血压治疗具有实际意义。当血压升高时，有些患者显示出自动调节的上限，超过该上限，脑血流量增加到静息值以上，而没有临床症状。在高血压患者中没有发现血管痉挛的证据。这些观察结果对了解高血压脑病的发病机制可能有重要意义。
Cerebral blood flow was studied by the arteriovenous oxygen difference method in patients with severe hypertension and in normotensive controls. The blood pressure was lowered to study the lower limit of autoregulation (the pressure below which cerebral blood flow decreases) and the pressure limit of brain hypoxia. Both limits were shifted upwards in the hypertensive patients, probably as a consequence of hypertrophy of the arteriolar walls. These findings have practical implications for antihypertensive therapy.When the blood pressure was raised some patients showed an upper limit of autoregulation beyond which an increase of cerebral blood flow above the resting value was seen without clinical symptoms. No evidence of vasospasm was found in any patient at high blood pressure. These observations may be of importance for the understanding of the pathogenesis of hypertensive encephalopathy.