Stability of a transdermal salmon calcitonin formulation.
Stability of a transdermal salmon calcitonin formulation.
复制标题
透皮鲑鱼降钙素制剂的稳定性。
DOI：
10.1080/713840326
复制
发表时间：
2003
期刊：
影响因子：
6
通讯作者：
Banga,AjayK
中科院分区：
文献类型：
--
作者：
Chang,Shu-Lun;Hofmann,GünterA;Zhang,Lei;Deftos,LeonardJ;Banga,AjayK
This study was designed to monitor the stability of salmon calcitonin during storage conditions, under the electric fields generated during iontophoresis and electroporation, in contact with transdermal glass diffusion cells, and during transport through skin. The formulation in a citrate buffer (pH 4.0) was stable in storage for short-term studies but degraded significantly on extended storage. Albumin was able to minimize adsorption in contact with glass surfaces, and aprotinin was able to minimize proteolytic degradation in contact with skin. The formulation was stable under electric field, but there was a loss due to adsorption if salt bridges were used.
