The impact of race and ethnicity on lipoprotein(a) levels and cardiovascular risk.
The impact of race and ethnicity on lipoprotein(a) levels and cardiovascular risk.
复制标题
种族和民族对脂蛋白（a）水平和心血管风险的影响。
DOI：
10.1097/mol.0000000000000753
复制
发表时间：
2021-06-01
影响因子：
4.4
通讯作者：
Reyes-Soffer G
中科院分区：
文献类型：
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作者：
Reyes-Soffer G
脂蛋白(A)是一种含脂蛋白的血浆循环载脂蛋白B100(ApoB)。它有一种独特的糖蛋白与apoB100结合，即载脂蛋白(A)[apo(A)]。大多数人表达两种apo(A)亚型，当它们与apoB100结合时，会产生两个循环中的Lp(A)粒子。Lp(A)水平是由遗传决定的，流行病学研究已确定Lp(A)水平升高是心血管疾病的一个因果风险因素。不同种族的Lp(A)水平不同，撒哈拉以南地区体面的黑人比白人的水平更高。与白人群体相比，少数族裔的研究在已出版的文献中代表较少。此外，用于测量Lp(A)水平的商业分析缺乏标准化，因此很难根据单个Lp(A)水平来评估风险，但风险似乎发生在人口的较高百分位数。最近一项使用英国生物库数据的研究强调了Lp(A)水平的种族差异以及所有种族之间心血管疾病风险的增加。这篇综述将突出LP(A)生物学和生理学，重点放在来自不同种族队列的现有数据上。有必要在不同的人群中进行研究，以了解他们是否比白人面临更高的风险。
Lipoprotein(a) is a plasma circulating apoB100 (apoB) containing lipoprotein. It has a unique glycoprotein bound to the apoB100, apolipoprotein (a) [apo(a)]. The majority of the population expresses two apo(a) isoforms, when bound to apoB100 they create two circulating Lp(a) particles. Lp(a) levels are genetically determined and epidemiological studies have established elevated levels of Lp(a) to be a causal risk factor of Cardiovascular Disease. Lp(a) levels differ across racial groups and Blacks of sub-Saharan decent have higher levels when compared to white. In comparison to white populations, studies in minorities are less represented in the published literature. Additionally, there is lack of standardization in the commercial assays used to measured Lp(a) levels, and hence it is difficult to assess risk based on individual Lp(a) levels, but risk seem to occur in the upper percentiles of the population. A recent study using data form the UK biobank highlights the racial differences in Lp(a) levels and the increase risk in cardiovascular disease amongst all races. This review will highlight Lp(a) biology and physiology with a focus on available data from racially diverse cohorts. There is a need to perform studies in diverse populations to understand if they are at higher risk than whites are.