Insights into the role of neuronal glucokinase.
Insights into the role of neuronal glucokinase.
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DOI：
10.1152/ajpendo.00034.2016
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发表时间：
2016-07-01
期刊：
影响因子：
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通讯作者：
Gardiner JV
中科院分区：
文献类型：
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作者：
De Backer I;Hussain SS;Bloom SR;Gardiner JV
葡萄糖激酶是神经元葡萄糖感知机制的关键组成部分，在控制一系列体内平衡过程的大脑区域中表达。在这篇综述中，我们详细介绍了最近发现的神经元葡萄糖激酶在血糖稳态和对低血糖的反调节反应以及在调节食欲中的作用。我们描述了我们知识中这些进步的临床意义，特别是对于开发糖尿病和肥胖症的新疗法。建议进行进一步的研究，以扩大我们的知识，并帮助我们努力应对糖尿病和肥胖症的流行。
Glucokinase is a key component of the neuronal glucose-sensing mechanism and is expressed in brain regions that control a range of homeostatic processes. In this review, we detail recently identified roles for neuronal glucokinase in glucose homeostasis and counterregulatory responses to hypoglycemia and in regulating appetite. We describe clinical implications from these advances in our knowledge, especially for developing novel treatments for diabetes and obesity. Further research required to extend our knowledge and help our efforts to tackle the diabetes and obesity epidemics is suggested.