Models of triple-stranded polynucleotides with optimised stereochemistry.
Models of triple-stranded polynucleotides with optimised stereochemistry.
复制标题
具有优化立体化学的三链多核苷酸模型。
DOI：
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发表时间：
1976
影响因子：
14.9
通讯作者：
P.J.C. Smith
中科院分区：
文献类型：
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作者：
S. Arnott;P. Bond;E. Selsing;P.J.C. Smith
提出了Poly(U)-Poly(A)-Poly(U)(两种形式)、Poly(U)-Poly d(A)-Poly(U)、Poly d(C)-Poly d(I)-Poly d(C)、Poly d(T)-Polyd(A)-Poly d(T)和Poly(I)-Poly(A)-Poly(I)的三链多核苷酸螺旋的详细模型。这些模型是使用计算机化的连接原子程序生成的，该程序保留了标准键长、键角和糖环构象，约束螺旋具有在X射线衍射实验中观察到的间距和对称性，并优化了包括氢键在内的非键原子间接触。讨论了这类络合物可能的生物学意义。
Detailed models are presented for the triple-stranded polynucleotide helices of poly (U)-poly (A)-poly (U) (two forms), poly (U)-poly d (A) -poly (U), poly d(C)-poly d(I)-poly d(C), poly d(T)-polyd(A)-poly d(T) and poly (I)-poly (A)-poly (I). The models were genrated using a computerized, linked-atom procedure which preserves standard bond lengths, bond anglesand sugar ring conformations, constrains the helices to have the pitches and symmetries observed in X-ray diffraction experiments, and optimises the non-bonded interatomic contacts including hydrogen bonds. The possible biological sigificance of such complexes is discussed.