Clinical characteristics and penile afferent neuronal function in patients with primary delayed ejaculation
Clinical characteristics and penile afferent neuronal function in patients with primary delayed ejaculation
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DOI：
10.1111/j.2047-2927.2013.00119.x
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发表时间：
2013-09
期刊：
影响因子：
4.5
通讯作者：
Jiadong Xia;You-feng Han;F. Pan;Liuhua Zhou;Yun Chen;Yun Chen;Yutian Dai;Yutian Dai
中科院分区：
文献类型：
--
作者：
Jiadong Xia;You-feng Han;F. Pan;Liuhua Zhou;Yun Chen;Yun Chen;Yutian Dai;Yutian Dai
原发性延迟射精(DE)是一种相对少见的疾病，尚未得到广泛研究。本研究旨在探讨原发性DE患者的临床特点及体感诱发电位对阴茎传入神经元功能的影响。24名原发性DE患者和24名年龄匹配的正常男性参加了这项研究。结果显示，初发DE患者的自慰频率明显高于对照组(P<0.05)，夜间排泄量较低，阴道内射精潜伏期较长，焦虑、抑郁情绪较高(分别为p=0.010，p=0.017，p<；0.001，p<；0.001，p<；0.001)。此外，患者的平均阴茎感觉阈值显著高于健康男性(p<；0.001)。DE组背神经体感诱发电位DNSEP潜伏期较对照组平均延长4.32ms(p<；0.001)。两组阴茎龟头体感诱发电位潜伏期差异无统计学意义(p=0.985)。与对照组相比，DE组DNSEP波幅显著降低(p=0.016)，而GPSEP波幅无明显变化(p=0.934)。这项研究表明，原发性DE患者的阴茎看起来比龟头更敏感和低兴奋性，对某种手淫技巧的适应(较高和特殊)可能与原发性DE的原因有关，这也与较低的夜间排泄量、较长的IELT、较高的焦虑和抑郁状态有关。
Primary delayed ejaculation (DE) is a relatively uncommon condition and has not been studied broadly. In this study, we aimed to investigate the clinical characteristics and penile afferent neuronal function using somatosensory evoked potentials in patients with primary DE. Twenty‐four patients with primary DE and 24 age‐matched normally potent men were enrolled in this study. Results indicated that patients with primary DE had remarkably higher frequency of masturbatory activity (especially, some with idiosyncratic styles), lower night emissions, longer intravaginal ejaculation latency time (IELT), higher anxiety and depression states (p = 0.010, p = 0.017, p < 0.001, p < 0.001, p < 0.001 respectively). In addition, the mean penile shaft sensory threshold values in the patients were considerably higher than those in the healthy men (p < 0.001). Mean latencies of dorsal nerve somatosensory evoked potential DNSEP were 4.32 ms longer in the DE group than those in the control group (p < 0.001). However, the latencies of glans penis somatosensory evoked potential (GPSEP) between the two group showed no significant difference (p = 0.985). At the same time, in comparison with the control group, the amplitudes of DNSEP were considerably lower in the DE group (p = 0.016), but not in the amplitudes of GPSEP (p = 0.934). This study indicates that the patients with primary DE appear to have penile shaft rather than glans hyposensitivity and hypoexcitability, and adaptation to a certain masturbatory technique (higher and idiosyncratic) may be related to the causes of primary DE, which is also associated with lower night emissions, longer IELT, higher anxiety and depression states.