Merkel cell carcinoma associated with stable chronic hemodialysis: A report of two cases.
Merkel cell carcinoma associated with stable chronic hemodialysis: A report of two cases.
复制标题
与稳定的慢性血液透析相关的默克尔细胞癌：两例报告。
DOI：
10.1111/1346-8138.13494
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发表时间：
2016
影响因子：
3.1
通讯作者：
and Yutaka Narisawa
中科院分区：
文献类型：
--
作者：
Kotaro Nagase;Hiromi Kimura;Shizuka Ogawa;Akiko Tara-Hashimoto;Shinichi Koba;Takuya Inoue;and Yutaka Narisawa
默克尔细胞癌（MCC）是一种罕见但侵袭性皮肤恶性肿瘤，与默克尔细胞多瘤病毒（MCPyV）有关。多项研究表明，免疫功能低下的个体中MCC的发病率高于一般人群。事实上，免疫抑制个体约占MCC患者人群的10%。在本报告中，我们描述了日本血液透析患者中的2例MCPyV相关MCC病例。在这两种情况下，MCC都存在于面部。尿毒症患者的细胞免疫和体液免疫都有所下降，透析患者患病毒介导的癌症（包括人乳头瘤病毒相关癌症）的风险很高。与尿毒症和透析相关的免疫功能障碍可能与发生MCC的高风险相关。
Merkel cell carcinoma (MCC) is a rare but aggressive cutaneous malignancy associated with the Merkel cell polyomavirus (MCPyV). Multiple studies have shown that the incidence of MCC is higher among immunocompromised individuals than among the general population. In fact, immunosuppressed individuals account for approximately 10% of the MCC patient population. In this report, we describe two cases of MCPyV‐related MCC in Japanese patients on hemodialysis. In both the cases, MCC was present on the face. Both cellular and humoral immunities have been shown to be decreased in uremic patients, and dialysis patients have a high risk of viral‐mediated cancers, including human papillomavirus‐associated cancers. Immune dysfunction related to uremia and dialysis may be associated with a high risk of developing MCC.