Bone mineral loss and cognitive impairment: The PRESENT project.
Bone mineral loss and cognitive impairment: The PRESENT project.
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DOI：
10.1097/md.0000000000012755
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发表时间：
2018-10
期刊：
影响因子：
1.6
通讯作者：
Suk SH
中科院分区：
文献类型：
--
作者：
Kang HG;Park HY;Ryu HU;Suk SH
低骨矿物质密度（BMD）与阿尔茨海默病及其严重程度相关，但在没有中风或痴呆病史的成年人（≥50岁）中，这种关联尚不清楚。我们使用简易精神状态检查（MMSE）评估了650名无卒中和痴呆的受试者（≥50岁）的BMD和认知功能，这些受试者在2009年1月至2010年12月期间被招募参加早期健康检查计划。平均年龄为62.9 ± 8.0岁，平均MMSE评分为27.6 ± 3.6。 根据世界卫生组织的标准，共有361名受试者的BMD降低：197名（30.3%）为骨量减少，154名（23.6%）为骨质疏松症。共有5.4%的男性受试者患有骨质疏松症，女性受试者为19.8%。在调整年龄、性别、教育和其他可能的混杂因素（例如高血压、糖尿病和吸烟）后，骨质减少组认知障碍的估计比值比为1.72（95%置信区间[CI] 1.09-2.14，P = 0.019）骨质疏松组为2.81（95%CI 1.78-4.45，P <0.001）。 低BMD与50岁及以上社区居住成年人的认知障碍相关，尤其是女性，无任何卒中或痴呆病史。一个以社区为基础的，早期生活，预防骨质疏松症的教育活动可能会降低痴呆症的发病率。
Low bone mineral density (BMD) is correlated with Alzheimer's disease and its severity, but the association remains unclear in adults (≥50 years) without a history of stroke or dementia. We assessed BMD and cognitive function using the Mini-Mental Status Examination (MMSE) in 650 stroke- and dementia-free subjects (≥50 years) who were recruited for an early health check-up program between January 2009 and December 2010. The mean age was 62.9 ± 8.0 years and mean MMSE score was 27.6 ± 3.6. A total of 361 subjects had reduced BMD: 197 (30.3%) had osteopenia and 154 (23.6%) had osteoporosis, based on criteria of world health organization. A total of 5.4% of the male subjects had osteoporosis, versus 19.8% of the female subjects. After adjusting for age, sex, education, and other possible confounding factors such as hypertension, diabetes mellitus, and smoking, the estimated odds ratio for cognitive impairment was 1.72 for the osteopenia group (95% confidence interval [CI] 1.09–2.14, P = .019) and 2.81 for the osteoporosis group (95% CI 1.78–4.45, P < .001). Low BMD is correlated with cognitive impairment in community-dwelling adults aged 50 years and above without any medical history of stroke or dementia, especially in women. A community-based, early life, preventive osteoporosis education campaign might decrease the incidence of dementia.