A new strategy with proton pump inhibitors for the prevention of acute exacerbations in COPD
A new strategy with proton pump inhibitors for the prevention of acute exacerbations in COPD
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DOI：
10.1177/1753465810392264
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发表时间：
2011-02
影响因子：
4.3
通讯作者：
Takahiko Sasaki;K. Nakayama;H. Yasuda;M. Yamaya
中科院分区：
文献类型：
--
作者：
Takahiko Sasaki;K. Nakayama;H. Yasuda;M. Yamaya
慢性阻塞性肺疾病（COPD）的急性加重，即呼吸道症状的急性恶化，通常导致预后不良。因此，成功预防和管理这种恶化对患者护理非常重要。病毒感染，主要是鼻病毒（RV），是COPD患者恶化的首要原因。据报道，质子泵抑制剂（PPIs）在体外可抑制人气道上皮细胞的RV感染。此外，PPIs在COPD患者中的临床试验导致普通感冒和COPD加重的发生率降低。在这篇综述中，我们讨论了COPD加重的意义，总结了一项已发表的关于低剂量PPIs对COPD加重影响的试验，并推测了这种影响的机制。
Acute exacerbations of chronic obstructive pulmonary disease (COPD), an acute worsening of respiratory symptoms, generally result in a poor prognosis. Successful prevention and management of such exacerbations is thus important for patient care. Viral infection, primarily with rhinovirus (RV), is the foremost cause of exacerbations in COPD patients. Proton pump inhibitors (PPIs) have been reported to inhibit RV infection in human airway epithelial cells in vitro. Furthermore, clinical trials of PPIs in patients with COPD resulted in a reduction in rates of both common cold and COPD exacerbations. In this review, we discuss the significance of COPD exacerbations, summarize a published trial of the effect of low-dose PPIs on COPD exacerbations, and postulate a mechanism for this effect.