Draft Genome Sequence of Mycobacterium tuberculosis Strain E186hv of Beijing B0/W Lineage with Reduced Virulence.
Draft Genome Sequence of Mycobacterium tuberculosis Strain E186hv of Beijing B0/W Lineage with Reduced Virulence.
复制标题
北京B0/W谱系低毒力结核分枝杆菌菌株E186hv的基因组序列草案。
DOI：
10.1128/genomea.00403-15
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Danilenko,VN
中科院分区：
文献类型：
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作者：
Shur,KV;Klimina,KM;Zakharevich,NV;Maslov,DA;Bekker,OB;Zaychikova,MV;Kamaev,EY;Kravchenko,MA;Skornyakov,SN;Zhang,Y;Danilenko,VN
我们报告了结核分枝杆菌菌株 E186hv 的基因组序列草案，该菌株属于北京 B0/W 谱系，从俄罗斯库尔干的一名患者中分离出来。该临床分离株表现出该谱系中罕见的毒力降低表型，并对异烟肼、利福平、乙胺丁醇、吡嗪酰胺和氧氟沙星具有耐药性。我们分析了与毒力相关的单核苷酸多态性 (SNP)。
We report a draft genome sequence of Mycobacterium tuberculosis strain E186hv, belonging to the Beijing B0/W lineage and isolated from a patient from Kurgan, Russia. This clinical isolate showed a reduced virulence phenotype unusual for this lineage and resistance to isoniazid, rifampin, ethambutol, pyrazinamide, and ofloxacin. We analyzed single nucleotide polymorphisms (SNPs) associated with virulence.