Pten in the breast tumor microenvironment: modeling tumor-stroma coevolution.
Pten in the breast tumor microenvironment: modeling tumor-stroma coevolution.
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DOI：
10.1158/0008-5472.can-10-3263
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发表时间：
2011-02-15
期刊：
影响因子：
11.2
通讯作者：
Ostrowski MC
中科院分区：
文献类型：
--
作者：
Wallace JA;Li F;Leone G;Ostrowski MC
假设人类实体肿瘤及其周围的微环境以促进肿瘤生长、侵袭和扩散的方式共同进化。小鼠癌症模型主要关注上皮肿瘤细胞的遗传变化，因此尚未对这一假设进行强有力的检验。我们最近开发了一种小鼠乳腺癌模型，该模型可消除基质成纤维细胞中的 PTEN 肿瘤抑制通路。值得注意的是，该模型在形态和分子水平上都类似于人类乳腺肿瘤。我们认为，此类模型反映了与人类乳腺癌相关的肿瘤-基质共同进化的亚型，因此将有助于定义支撑肿瘤-基质串扰的机制。此外，这些模型还应有助于根据人类乳腺肿瘤所包含的微环境亚型以及肿瘤亚型对人类乳腺肿瘤进行分子分类。
Solid human tumors and their surrounding microenvironment are hypothesized to co-evolve in a manner that promotes tumor growth, invasiveness and spread. Mouse models of cancer have focused on genetic changes in the epithelial tumor cells and therefore have not robustly tested this hypothesis. We have recently developed a murine breast cancer model that ablates the PTEN tumor suppressor pathway in stromal fibroblasts. Remarkably, the model resembles human breast tumors both at morphologic and molecular levels. We propose that such models reflect subtypes of tumor-stromal co-evolution relevant to human breast cancer, and will therefore be useful in defining the mechanisms that underpin tumor-stroma crosstalk. Additionally, these models should also aid in molecularly classifying human breast tumors based on both the microenvironment subtypes they contain as well as on the tumor subtype.