Relationship between transcardiac extraction of aldosterone and left ventricular remodeling in patients with first acute myocardial infarction: Extracting aldosterone through the heart promotes ventricular remodeling after acute myocardial infarction
Relationship between transcardiac extraction of aldosterone and left ventricular remodeling in patients with first acute myocardial infarction: Extracting aldosterone through the heart promotes ventricular remodeling after acute myocardial infarction
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DOI：
10.1016/s0735-1097(01)01539-x
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发表时间：
2001-11-01
影响因子：
24
通讯作者：
Kinoshita, M
中科院分区：
文献类型：
--
作者：
Hayashi, M;Tsutamoto, T;Kinoshita, M
目的评价急性心肌梗死（AMI）患者血浆醛固酮（ALD）是否通过心脏提取或产生，并确定经心提取血浆ALD与左心室（LV）重构的关系。虽然我们证明了循环ALD是通过衰竭的心脏提取的，并且经心脏提取的ALD与充血性心力衰竭患者左室舒张末期容积指数（LVEDVI）相关，但报道了梗死大鼠心脏中ALD合酶的存在和升高，提示AMI患者心脏中存在ALD。方法对57例血管重建术成功并应用依那普利治疗的急性期及术后1个月首次急性心肌梗死患者的主动脉根（Ao）和冠状动脉窦（CS）血浆ALD进行测定。我们还测量了CS中血浆前胶原III型氨基末端肽（PIIINP）。结果急性期血浆ALD在CS组明显低于Ac组(84.7 +/-6.3 pg/ml vs. 105.5 +/-8.0 pg/ml, p
Objectives The purpose of this study was to evaluate whether plasma aldosterone (ALD) is extracted or produced through the heart in patients with acute myocardial infarction (AMI) and to determine the relationship between transcardiac extraction of plasma ALD and left ventricular (LV) remodeling.Background Although we demonstrated that circulating ALD was extracted through the failing heart and that transcardiac extraction of ALD correlated with LV end-diastolic volume index (LVEDVI) in patients with congestive heart failure, the existence and increase of ALD synthase in the hearts of infarct rats were reported, suggesting cardiac: production of ALD in patients with AMI.Methods We measured plasma ALD in the aortic root (Ao) and coronary sinus (CS) in 57 consecutive patients who received successful revascularization and enalapril, with first AMI at acute phase and after one month. We also measured plasma procollagen type III aminoterminal peptide (PIIINP) in the CS.Results Plasma ALD was significantly lower in the CS than it was in the Ac, at the acute phase (84.7 +/-6.3 pg/ml vs. 105.5 +/-8.0 pg/ml, p